TY - JOUR
T1 - Ontario Neurodegenerative Disease Research Initiative (ONDRI)
T2 - Structural MRI Methods and Outcome Measures
AU - The ONDRI Investigators
AU - Ramirez, Joel
AU - Holmes, Melissa F.
AU - Scott, Christopher J.M.
AU - Ozzoude, Miracle
AU - Adamo, Sabrina
AU - Szilagyi, Gregory M.
AU - Goubran, Maged
AU - Gao, Fuqiang
AU - Arnott, Stephen R.
AU - Lawrence-Dewar, Jane M.
AU - Beaton, Derek
AU - Strother, Stephen C.
AU - Munoz, Douglas P.
AU - Masellis, Mario
AU - Swartz, Richard H.
AU - Bartha, Robert
AU - Symons, Sean P.
AU - Black, Sandra E.
AU - Strong, Michael
AU - Kleinstiver, Peter
AU - Rashkovan, Natalie
AU - Bronskill, Susan
AU - Black, Sandra E.
AU - Borrie, Michael
AU - Finger, Elizabeth
AU - Fischer, Corinne
AU - Frank, Andrew
AU - Freedman, Morris
AU - Kumar, Sanjeev
AU - Pasternak, Stephen
AU - Pollock, Bruce
AU - Rajji, Tarek
AU - Seitz, Dallas
AU - Tang-Wai, David
AU - Tartaglia, Carmela
AU - Varriano, Brenda
AU - Abrahao, Agessandro
AU - Chum, Marvin
AU - Shoesmith, Christen
AU - Turnbull, John
AU - Zinman, Lorne
AU - Lawrence-Dewar, Jane
AU - Kwan, Donna
AU - Tan, Brian
AU - Fraser, Julia
AU - McIlroy, Bill
AU - Cornish, Ben
AU - Van Ooteghem, Karen
AU - Faria, Frederico
AU - Roberts, Angela
N1 - Publisher Copyright:
© Copyright © 2020 Ramirez, Holmes, Scott, Ozzoude, Adamo, Szilagyi, Goubran, Gao, Arnott, Lawrence-Dewar, Beaton, Strother, Munoz, Masellis, Swartz, Bartha, Symons, Black and the ONDRI Investigators.
PY - 2020/8/11
Y1 - 2020/8/11
N2 - The Ontario Neurodegenerative Research Initiative (ONDRI) is a 3 years multi-site prospective cohort study that has acquired comprehensive multiple assessment platform data, including 3T structural MRI, from neurodegenerative patients with Alzheimer's disease, mild cognitive impairment, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and cerebrovascular disease. This heterogeneous cross-section of patients with complex neurodegenerative and neurovascular pathologies pose significant challenges for standard neuroimaging tools. To effectively quantify regional measures of normal and pathological brain tissue volumes, the ONDRI neuroimaging platform implemented a semi-automated MRI processing pipeline that was able to address many of the challenges resulting from this heterogeneity. The purpose of this paper is to serve as a reference and conceptual overview of the comprehensive neuroimaging pipeline used to generate regional brain tissue volumes and neurovascular marker data that will be made publicly available online.
AB - The Ontario Neurodegenerative Research Initiative (ONDRI) is a 3 years multi-site prospective cohort study that has acquired comprehensive multiple assessment platform data, including 3T structural MRI, from neurodegenerative patients with Alzheimer's disease, mild cognitive impairment, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and cerebrovascular disease. This heterogeneous cross-section of patients with complex neurodegenerative and neurovascular pathologies pose significant challenges for standard neuroimaging tools. To effectively quantify regional measures of normal and pathological brain tissue volumes, the ONDRI neuroimaging platform implemented a semi-automated MRI processing pipeline that was able to address many of the challenges resulting from this heterogeneity. The purpose of this paper is to serve as a reference and conceptual overview of the comprehensive neuroimaging pipeline used to generate regional brain tissue volumes and neurovascular marker data that will be made publicly available online.
KW - Alzheimer
KW - MRI
KW - Parkinson
KW - amyotrophic lateral sclerosis
KW - cerebral small vessel disease
KW - cerebrovascular disease
KW - frontotemporal dementia
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85089938970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089938970&partnerID=8YFLogxK
U2 - 10.3389/fneur.2020.00847
DO - 10.3389/fneur.2020.00847
M3 - Article
C2 - 32849254
AN - SCOPUS:85089938970
SN - 1664-2295
VL - 11
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 847
ER -