Ontogeny of arousal

David H. Crowell*, Lee J. Brooks, Michael Corwin, Sally Davidson-Ward, Carl E. Hunt, Linda E. Kapuniai, Michael R. Neuman, Jean Silvestri, Larry Tinsley, Debra E. Weese-Mayer, Juliann Di Fiore, Mark Peucker, John S. Grove, James W. Pearce

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Ontogeny of arousal data constitute a vital supplement to the sparse literature on spontaneous neuronal activity. These data demonstrate that measurable infant spontaneous arousals (SAs) with an inherent oscillatory entrainment occur six times more in active sleep than in quiet sleep of the same duration and are identifiable as a human neurobiologic function. These SAs are not significantly associated with race or ethnicity, gender, total hours spent sleeping, percent time spent in active or quiet sleep, preterm status, history of a life-threatening event, having had a sibling who died of sudden infant death syndrome (SIDS), or having had a mother who smoked during this pregnancy. As measurable neurophysiologic events, SAs establish parameters for research at molecular and molar levels focusing on several critical areas: (1) the neuronal control of SA related to neurotransmitters, (2) as a significant antecedent factor in clinical cardiorespiratory events occurring in infants at high epidemiologic risk for SIDS; (3) as a regulatory biologic factor underlying temperament and executive cognitive functioning, and (4) morbidity and mortality effects possibly related to therapeutic interventions that alter SA levels.

Original languageEnglish (US)
Pages (from-to)290-300
Number of pages11
JournalJournal of Clinical Neurophysiology
Volume21
Issue number4
DOIs
StatePublished - 2004

Keywords

  • Arousal Index
  • Infant
  • Polysomnography
  • Spontaneous arousals
  • Transient EEG arousal

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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  • Cite this

    Crowell, D. H., Brooks, L. J., Corwin, M., Davidson-Ward, S., Hunt, C. E., Kapuniai, L. E., Neuman, M. R., Silvestri, J., Tinsley, L., Weese-Mayer, D. E., Di Fiore, J., Peucker, M., Grove, J. S., & Pearce, J. W. (2004). Ontogeny of arousal. Journal of Clinical Neurophysiology, 21(4), 290-300. https://doi.org/10.1097/01.WNP.0000141754.03598.DC