Oocyte donation: lessons from the past, directions for the future

Steven R. Lindheim*, Susan C. Klock

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Oocyte donation has its origins in the clandestine use of donated sperm more than 140 years ago. Since first described in 1983, oocyte donation has resulted in more than 50,000 births in the United States alone and today now accounts for more than 10% of all IVF cycles performed yearly in the United States. The use of donated oocytes has changed the human reproductive landscape, challenging the traditional norms of conception and parenthood. Oocyte donation has also provided a unique scientific model that separates the egg from the uterus, allowing the independent study of each in normal physiologic and pathological conditions and providing insights into the fundamental aspects of reproduction, cell biology, and genetics. This Views and Reviews takes us through the historical development of oocyte donation, its scientific insights, and its application to daily practice and management, as well as insights into what the future may hold for this field.

Original languageEnglish (US)
Pages (from-to)979-980
Number of pages2
JournalFertility and Sterility
Issue number6
StatePublished - Nov 2018


  • Oocyte donation
  • historical
  • innovation
  • medical
  • uterus

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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