TY - JOUR
T1 - Oophorectomy versus salpingo-oophorectomy in Turner syndrome patients with Y-chromosome material
T2 - Clinical experience and current practice patterns assessment
AU - Kanakatti Shankar, Roopa
AU - Inge, Thomas H.
AU - Gutmark-Little, Iris
AU - Backeljauw, Philippe F.
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background/purpose Gonadectomy is recommended in Turner syndrome (TS) patients with Y-chromosome material due to high risk of tumor in the dysgenetic gonads. No recommendations exist on whether concurrent salpingectomy should be performed.Methods A retrospective chart review of surgical procedure and histopathology in TS patients with Y-chromosome enrolled in a TS database was undertaken at Cincinnati Children's Hospital Medical Center. An electronic survey was sent to members of the International Pediatric Endosurgery Group to assess prevalent practice patterns and attitudes on gonadectomy and concurrent salpingectomy in this population.Results In March 2011, 12/158 (8%) TS girls (mean age 6.6 years) enrolled in the database had TS with Y-chromosome. Gonadoblastoma was identified in 4/12 (33%) patients and 2/4 had malignant transformation to dysgerminoma and teratoma. Approach to gonadectomy was varied and 3/12 had concurrent salpingectomy. Fifty-four laparoscopic surgeons responded to the survey with no clear consensus on whether salpingectomy should be concurrently performed.Conclusions TS patients with Y-chromosome have an increased risk of gonadal tumor development and gonadectomy is recommended. While there is no consensus among pediatric laparoscopic surgeons on concurrent salpingectomy, it is reasonable to consider this combination procedure.
AB - Background/purpose Gonadectomy is recommended in Turner syndrome (TS) patients with Y-chromosome material due to high risk of tumor in the dysgenetic gonads. No recommendations exist on whether concurrent salpingectomy should be performed.Methods A retrospective chart review of surgical procedure and histopathology in TS patients with Y-chromosome enrolled in a TS database was undertaken at Cincinnati Children's Hospital Medical Center. An electronic survey was sent to members of the International Pediatric Endosurgery Group to assess prevalent practice patterns and attitudes on gonadectomy and concurrent salpingectomy in this population.Results In March 2011, 12/158 (8%) TS girls (mean age 6.6 years) enrolled in the database had TS with Y-chromosome. Gonadoblastoma was identified in 4/12 (33%) patients and 2/4 had malignant transformation to dysgerminoma and teratoma. Approach to gonadectomy was varied and 3/12 had concurrent salpingectomy. Fifty-four laparoscopic surgeons responded to the survey with no clear consensus on whether salpingectomy should be concurrently performed.Conclusions TS patients with Y-chromosome have an increased risk of gonadal tumor development and gonadectomy is recommended. While there is no consensus among pediatric laparoscopic surgeons on concurrent salpingectomy, it is reasonable to consider this combination procedure.
KW - Gonadoblastoma
KW - Laparoscopic gonadectomy
KW - Salpingectomy
KW - Turner syndrome
KW - Y-chromosome
UR - http://www.scopus.com/inward/record.url?scp=84919457939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919457939&partnerID=8YFLogxK
U2 - 10.1016/j.jpedsurg.2014.06.012
DO - 10.1016/j.jpedsurg.2014.06.012
M3 - Article
C2 - 25475798
AN - SCOPUS:84919457939
SN - 0022-3468
VL - 49
SP - 1585
EP - 1588
JO - Journal of pediatric surgery
JF - Journal of pediatric surgery
IS - 11
ER -