OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection

Jie Lu; Ping Li; Ke Ma; Yang Li; Hui Yuan; Junming Zhu; Weixun Duan; Jingsong Ou; Yonghong Huang; Long Wu; Xueliang Pan; Hui Zhang; Jie Du; Yulin Li

doi:10.1038/s41467-021-23787-5

OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection

Jie Lu, Ping Li, Ke Ma, Yang Li, Hui Yuan, Junming Zhu, Weixun Duan, Jingsong Ou, Yonghong Huang, Long Wu, Xueliang Pan, Hui Zhang, Jie Du^*, Yulin Li^*

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Following hospital discharge, patients with type A acute aortic dissection (TA-AAD) may present an increase in mortality risk. However, little is known about specific biomarkers associated with post-discharge survival, and there is a paucity of prognostic markers associated with TA-AAD. Here, we identify nine candidate proteins specific for patietns with TA-AAD in a cross-sectional dataset by unbiased protein screening and in-depth bioinformatic analyses. In addition, we explore their association with short-term and long-term mortality in a derivation cohort of patients with TA-AAD, including an internal (n = 300) and external (n = 236) dataset. An elevated osteoprotegerin (OPG)/tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) ratio was the strongest predictor of overall, 30-day, post-30-day mortality in both datasets and was confirmed to be a strong predictor of mortality in an independent validation cohort (n = 400). Based on OPG/TRAIL ratio-guided risk stratification, patients at high risk (>33) had a higher 1-year mortality (55.6% vs. 4.3%; 68.2% vs. 2.6%) than patients at low risk (<4) in both cohorts. In Conclusion, we show that an elevated OPG/TRAIL ratio is associated with a significant increase in short-term and long-term mortality in patients with TA-AAD.

Original language	English (US)
Article number	3401
Journal	Nature communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-23787-5
State	Published - Dec 1 2021

Funding

We thank Dr. Jian Cui (Shanghai BioGenius Biotechnology Co., Ltd) for bioinformatics assistance. This work was supported by the National Science Foundation of China [grant numbers 91539121, 81930014, 81870339); Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, China [grant number PXM2014-014226-000012); National Key R&D Program of China [grant number 2016YFC0903001].

ASJC Scopus subject areas

General Physics and Astronomy
General Chemistry
General Biochemistry, Genetics and Molecular Biology

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title = "OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection",

abstract = "Following hospital discharge, patients with type A acute aortic dissection (TA-AAD) may present an increase in mortality risk. However, little is known about specific biomarkers associated with post-discharge survival, and there is a paucity of prognostic markers associated with TA-AAD. Here, we identify nine candidate proteins specific for patietns with TA-AAD in a cross-sectional dataset by unbiased protein screening and in-depth bioinformatic analyses. In addition, we explore their association with short-term and long-term mortality in a derivation cohort of patients with TA-AAD, including an internal (n = 300) and external (n = 236) dataset. An elevated osteoprotegerin (OPG)/tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) ratio was the strongest predictor of overall, 30-day, post-30-day mortality in both datasets and was confirmed to be a strong predictor of mortality in an independent validation cohort (n = 400). Based on OPG/TRAIL ratio-guided risk stratification, patients at high risk (>33) had a higher 1-year mortality (55.6% vs. 4.3%; 68.2% vs. 2.6%) than patients at low risk (<4) in both cohorts. In Conclusion, we show that an elevated OPG/TRAIL ratio is associated with a significant increase in short-term and long-term mortality in patients with TA-AAD.",

author = "Jie Lu and Ping Li and Ke Ma and Yang Li and Hui Yuan and Junming Zhu and Weixun Duan and Jingsong Ou and Yonghong Huang and Long Wu and Xueliang Pan and Hui Zhang and Jie Du and Yulin Li",

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T1 - OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection

AU - Lu, Jie

AU - Li, Ping

AU - Ma, Ke

AU - Li, Yang

AU - Yuan, Hui

AU - Zhu, Junming

AU - Duan, Weixun

AU - Ou, Jingsong

AU - Huang, Yonghong

AU - Wu, Long

AU - Pan, Xueliang

AU - Zhang, Hui

AU - Du, Jie

AU - Li, Yulin

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Following hospital discharge, patients with type A acute aortic dissection (TA-AAD) may present an increase in mortality risk. However, little is known about specific biomarkers associated with post-discharge survival, and there is a paucity of prognostic markers associated with TA-AAD. Here, we identify nine candidate proteins specific for patietns with TA-AAD in a cross-sectional dataset by unbiased protein screening and in-depth bioinformatic analyses. In addition, we explore their association with short-term and long-term mortality in a derivation cohort of patients with TA-AAD, including an internal (n = 300) and external (n = 236) dataset. An elevated osteoprotegerin (OPG)/tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) ratio was the strongest predictor of overall, 30-day, post-30-day mortality in both datasets and was confirmed to be a strong predictor of mortality in an independent validation cohort (n = 400). Based on OPG/TRAIL ratio-guided risk stratification, patients at high risk (>33) had a higher 1-year mortality (55.6% vs. 4.3%; 68.2% vs. 2.6%) than patients at low risk (<4) in both cohorts. In Conclusion, we show that an elevated OPG/TRAIL ratio is associated with a significant increase in short-term and long-term mortality in patients with TA-AAD.

AB - Following hospital discharge, patients with type A acute aortic dissection (TA-AAD) may present an increase in mortality risk. However, little is known about specific biomarkers associated with post-discharge survival, and there is a paucity of prognostic markers associated with TA-AAD. Here, we identify nine candidate proteins specific for patietns with TA-AAD in a cross-sectional dataset by unbiased protein screening and in-depth bioinformatic analyses. In addition, we explore their association with short-term and long-term mortality in a derivation cohort of patients with TA-AAD, including an internal (n = 300) and external (n = 236) dataset. An elevated osteoprotegerin (OPG)/tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) ratio was the strongest predictor of overall, 30-day, post-30-day mortality in both datasets and was confirmed to be a strong predictor of mortality in an independent validation cohort (n = 400). Based on OPG/TRAIL ratio-guided risk stratification, patients at high risk (>33) had a higher 1-year mortality (55.6% vs. 4.3%; 68.2% vs. 2.6%) than patients at low risk (<4) in both cohorts. In Conclusion, we show that an elevated OPG/TRAIL ratio is associated with a significant increase in short-term and long-term mortality in patients with TA-AAD.

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OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection

Abstract

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