Ophthalmic presentation of giant cell arteritis in African-Americans

S. T. Garrity, M. Pistilli, M. S. Vaphiades, N. Q. Richards, P. S. Subramanian, P. R. Rosa, B. L. Lam, B. J. Osborne, G. T. Liu, K. E. Duncan, R. K. Shin, Nicholas J Volpe, K. S. Shindler, M. S. Lee, M. L. Moster, E. H. Tracey, S. E. Cuprill-Nilson, M. A. Tamhankar

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Abstract

PurposeTo determine the differences in the presentation of ophthalmic giant cell arteritis between African-Americans and Caucasians.MethodsThis was a multicenter retrospective case series comparing African-American patients with ophthalmic GCA to a previously published Caucasian cohort. Neuro-ophthalmic centers across the United States were contacted to provide data on African-American patients with biopsy-proven ophthalmic giant cell arteritis. The differences between African-American and Caucasian patients with respect to multiple variables, including age, sex, systemic and ophthalmic signs and symptoms, ocular ischemic lesions, and laboratory results were studied.ResultsThe Caucasian cohort was slightly older (mean=76.1 years) than the African-American cohort (mean=72.6 years, P=0.03), and there was no difference in sex distribution between the two cohorts. Headache, neck pain, and anemia were more frequent, while jaw claudication was less frequent in African-Americans (P<0.01, <0.001, 0.02, and 0.03 respectively). Acute vision loss was the most common presentation of giant cell arteritis in both groups, though it was less common in African-Americans (78 vs 98% of Caucasians, P<0.001). Eye pain was more common in African-Americans (28 vs 8% of Caucasians, P<0.01).ConclusionsThe presenting features of ophthalmic giant cell arteritis in African-Americans and Caucasians are not markedly different, although a few significant differences exist, including higher rates of headache, neck pain, anemia, and eye pain, and lower rates of jaw claudication and acute vision loss in African-Americans. Persons presenting with suspicious signs and symptoms should undergo evaluation for giant cell arteritis regardless of race.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalEye (Basingstoke)
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2017

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Giant Cell Arteritis
African Americans
Eye Pain
Neck Pain
Jaw
Signs and Symptoms
Headache
Anemia
Cells
Giant
Sex Distribution
Biopsy

ASJC Scopus subject areas

  • Ophthalmology
  • Arts and Humanities(all)

Cite this

Garrity, S. T., Pistilli, M., Vaphiades, M. S., Richards, N. Q., Subramanian, P. S., Rosa, P. R., ... Tamhankar, M. A. (2017). Ophthalmic presentation of giant cell arteritis in African-Americans. Eye (Basingstoke), 31(1), 113-118. https://doi.org/10.1038/eye.2016.199
Garrity, S. T. ; Pistilli, M. ; Vaphiades, M. S. ; Richards, N. Q. ; Subramanian, P. S. ; Rosa, P. R. ; Lam, B. L. ; Osborne, B. J. ; Liu, G. T. ; Duncan, K. E. ; Shin, R. K. ; Volpe, Nicholas J ; Shindler, K. S. ; Lee, M. S. ; Moster, M. L. ; Tracey, E. H. ; Cuprill-Nilson, S. E. ; Tamhankar, M. A. / Ophthalmic presentation of giant cell arteritis in African-Americans. In: Eye (Basingstoke). 2017 ; Vol. 31, No. 1. pp. 113-118.
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title = "Ophthalmic presentation of giant cell arteritis in African-Americans",
abstract = "PurposeTo determine the differences in the presentation of ophthalmic giant cell arteritis between African-Americans and Caucasians.MethodsThis was a multicenter retrospective case series comparing African-American patients with ophthalmic GCA to a previously published Caucasian cohort. Neuro-ophthalmic centers across the United States were contacted to provide data on African-American patients with biopsy-proven ophthalmic giant cell arteritis. The differences between African-American and Caucasian patients with respect to multiple variables, including age, sex, systemic and ophthalmic signs and symptoms, ocular ischemic lesions, and laboratory results were studied.ResultsThe Caucasian cohort was slightly older (mean=76.1 years) than the African-American cohort (mean=72.6 years, P=0.03), and there was no difference in sex distribution between the two cohorts. Headache, neck pain, and anemia were more frequent, while jaw claudication was less frequent in African-Americans (P<0.01, <0.001, 0.02, and 0.03 respectively). Acute vision loss was the most common presentation of giant cell arteritis in both groups, though it was less common in African-Americans (78 vs 98{\%} of Caucasians, P<0.001). Eye pain was more common in African-Americans (28 vs 8{\%} of Caucasians, P<0.01).ConclusionsThe presenting features of ophthalmic giant cell arteritis in African-Americans and Caucasians are not markedly different, although a few significant differences exist, including higher rates of headache, neck pain, anemia, and eye pain, and lower rates of jaw claudication and acute vision loss in African-Americans. Persons presenting with suspicious signs and symptoms should undergo evaluation for giant cell arteritis regardless of race.",
author = "Garrity, {S. T.} and M. Pistilli and Vaphiades, {M. S.} and Richards, {N. Q.} and Subramanian, {P. S.} and Rosa, {P. R.} and Lam, {B. L.} and Osborne, {B. J.} and Liu, {G. T.} and Duncan, {K. E.} and Shin, {R. K.} and Volpe, {Nicholas J} and Shindler, {K. S.} and Lee, {M. S.} and Moster, {M. L.} and Tracey, {E. H.} and Cuprill-Nilson, {S. E.} and Tamhankar, {M. A.}",
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Garrity, ST, Pistilli, M, Vaphiades, MS, Richards, NQ, Subramanian, PS, Rosa, PR, Lam, BL, Osborne, BJ, Liu, GT, Duncan, KE, Shin, RK, Volpe, NJ, Shindler, KS, Lee, MS, Moster, ML, Tracey, EH, Cuprill-Nilson, SE & Tamhankar, MA 2017, 'Ophthalmic presentation of giant cell arteritis in African-Americans' Eye (Basingstoke), vol. 31, no. 1, pp. 113-118. https://doi.org/10.1038/eye.2016.199

Ophthalmic presentation of giant cell arteritis in African-Americans. / Garrity, S. T.; Pistilli, M.; Vaphiades, M. S.; Richards, N. Q.; Subramanian, P. S.; Rosa, P. R.; Lam, B. L.; Osborne, B. J.; Liu, G. T.; Duncan, K. E.; Shin, R. K.; Volpe, Nicholas J; Shindler, K. S.; Lee, M. S.; Moster, M. L.; Tracey, E. H.; Cuprill-Nilson, S. E.; Tamhankar, M. A.

In: Eye (Basingstoke), Vol. 31, No. 1, 01.01.2017, p. 113-118.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ophthalmic presentation of giant cell arteritis in African-Americans

AU - Garrity, S. T.

AU - Pistilli, M.

AU - Vaphiades, M. S.

AU - Richards, N. Q.

AU - Subramanian, P. S.

AU - Rosa, P. R.

AU - Lam, B. L.

AU - Osborne, B. J.

AU - Liu, G. T.

AU - Duncan, K. E.

AU - Shin, R. K.

AU - Volpe, Nicholas J

AU - Shindler, K. S.

AU - Lee, M. S.

AU - Moster, M. L.

AU - Tracey, E. H.

AU - Cuprill-Nilson, S. E.

AU - Tamhankar, M. A.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - PurposeTo determine the differences in the presentation of ophthalmic giant cell arteritis between African-Americans and Caucasians.MethodsThis was a multicenter retrospective case series comparing African-American patients with ophthalmic GCA to a previously published Caucasian cohort. Neuro-ophthalmic centers across the United States were contacted to provide data on African-American patients with biopsy-proven ophthalmic giant cell arteritis. The differences between African-American and Caucasian patients with respect to multiple variables, including age, sex, systemic and ophthalmic signs and symptoms, ocular ischemic lesions, and laboratory results were studied.ResultsThe Caucasian cohort was slightly older (mean=76.1 years) than the African-American cohort (mean=72.6 years, P=0.03), and there was no difference in sex distribution between the two cohorts. Headache, neck pain, and anemia were more frequent, while jaw claudication was less frequent in African-Americans (P<0.01, <0.001, 0.02, and 0.03 respectively). Acute vision loss was the most common presentation of giant cell arteritis in both groups, though it was less common in African-Americans (78 vs 98% of Caucasians, P<0.001). Eye pain was more common in African-Americans (28 vs 8% of Caucasians, P<0.01).ConclusionsThe presenting features of ophthalmic giant cell arteritis in African-Americans and Caucasians are not markedly different, although a few significant differences exist, including higher rates of headache, neck pain, anemia, and eye pain, and lower rates of jaw claudication and acute vision loss in African-Americans. Persons presenting with suspicious signs and symptoms should undergo evaluation for giant cell arteritis regardless of race.

AB - PurposeTo determine the differences in the presentation of ophthalmic giant cell arteritis between African-Americans and Caucasians.MethodsThis was a multicenter retrospective case series comparing African-American patients with ophthalmic GCA to a previously published Caucasian cohort. Neuro-ophthalmic centers across the United States were contacted to provide data on African-American patients with biopsy-proven ophthalmic giant cell arteritis. The differences between African-American and Caucasian patients with respect to multiple variables, including age, sex, systemic and ophthalmic signs and symptoms, ocular ischemic lesions, and laboratory results were studied.ResultsThe Caucasian cohort was slightly older (mean=76.1 years) than the African-American cohort (mean=72.6 years, P=0.03), and there was no difference in sex distribution between the two cohorts. Headache, neck pain, and anemia were more frequent, while jaw claudication was less frequent in African-Americans (P<0.01, <0.001, 0.02, and 0.03 respectively). Acute vision loss was the most common presentation of giant cell arteritis in both groups, though it was less common in African-Americans (78 vs 98% of Caucasians, P<0.001). Eye pain was more common in African-Americans (28 vs 8% of Caucasians, P<0.01).ConclusionsThe presenting features of ophthalmic giant cell arteritis in African-Americans and Caucasians are not markedly different, although a few significant differences exist, including higher rates of headache, neck pain, anemia, and eye pain, and lower rates of jaw claudication and acute vision loss in African-Americans. Persons presenting with suspicious signs and symptoms should undergo evaluation for giant cell arteritis regardless of race.

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Garrity ST, Pistilli M, Vaphiades MS, Richards NQ, Subramanian PS, Rosa PR et al. Ophthalmic presentation of giant cell arteritis in African-Americans. Eye (Basingstoke). 2017 Jan 1;31(1):113-118. https://doi.org/10.1038/eye.2016.199