Ophthalmologic Findings in Acquired Immune Deficiency Syndrome (Aids)

May Khadem, Steve B. Kalish, Joanne Goldsmith, Carl Fetkenhour, Richard B. O’grady, John P. Phair*, Martin Chrobak

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Forty-one homosexually active men had ophthalmologic and immunologic evaluations. Four of eight with acquired immune deficiency syndrome (AIDS) had abnormal ocular findings that included cotton-wool spots, retinal hemorrhages, cytomegalovirus, retinitis and conjunctivitis due to cytomegalovirus, and keratoconjunctivitis sicca. The other four patients with AIDS and 33 homosexual male controls had normal ocular examinations. Patients with AIDS and abnormal eye findings had a notably lower total leukocyte count, absolute lymphocyte count, percentage T-helper lymphocytes, helper-suppressor lymphocyte ratio, hematocrit level, and platelet count than patients with AIDS and normal results on eye examination or controls. All patients with AIDS and abnormal eye examination results died; the four other patients with AIDS and normal eye findings remain alive. These observations suggest that ophthalmologic abnormalities are common in patients with AIDS, are associated with severe immunoregulatory abnormalities, and carry a poor prognosis.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalArchives of ophthalmology
Volume102
Issue number2
DOIs
StatePublished - Feb 1984

ASJC Scopus subject areas

  • Ophthalmology

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