Opportunistic infections complicating solid organ transplantation with alemtuzumab induction

M. Helfrich, M. G. Ison*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Opportunistic infections remain a common complication of solid organ transplantation. Despite significant changes in immunosuppression and infectious diseases prophylaxis, data are limited on the contemporary epidemiology and outcomes of opportunistic infections. Alemtuzumab, a potent lymphocyte-depleting antibody, has been used with increased frequency in solid organ transplant recipients in the last decade. A literature review was performed to summarize the current understanding of the epidemiology, risk factors, and outcomes of opportunistic infections complicating solid organ transplantation with and without alemtuzumab induction therapy. Areas where data are limited regarding opportunistic infections in solid organ transplantation with alemtuzumab induction are indicated.

Original languageEnglish (US)
Pages (from-to)627-636
Number of pages10
JournalTransplant Infectious Disease
Volume17
Issue number5
DOIs
StatePublished - Jan 1 2015

Keywords

  • Alemtuzumab
  • Opportunistic infection
  • SOT

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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