Opportunistic Infections in Transplant Patients

Rebecca Kumar, Michael G. Ison*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

Transplants have become common with excellent patient and graft outcomes owing to advances in surgical technique, immunosuppression, and antimicrobial prophylaxis. In 2017, 34,770 solid organ transplants were performed in the United States. For solid organ transplant recipients, infection remains a common complication owing to the regimens required to prevent rejection. Opportunistic infections, which are infections that are generally of lower virulence within a healthy host but cause more severe and frequent disease in immunosuppressed individuals, typically occur in the period 1 month to 1 year after transplantation. This article focuses on opportunistic infections in the solid organ transplant recipient.

Original languageEnglish (US)
Pages (from-to)1143-1157
Number of pages15
JournalInfectious disease clinics of North America
Volume33
Issue number4
DOIs
StatePublished - Dec 2019

Funding

Disclosures: R. Kumar is supported through T32 AI095207 (NIH). M.G. Ison reports being a paid member of the DSMB for GlaxoSmithKlein and Shionogi; personal consulting fees from Celltrione, Genentech/Roche, Janssen, Seqirus, Shionogi, Viracor Eurofins, and VirBio; payments to Northwestern University by AiCuris, Chimerix, Emergent BioScience, Genentech/Roche, Gilead, Janssen, and Shire for research; and for having served as an nonpaid consultant for GlaxoSmithKlein, Romark, and Vertex.

Keywords

  • BK virus
  • Cytomegalovirus
  • Infection
  • Nocardia
  • Organ transplant
  • Polyoma virus
  • Toxoplasmosis
  • Transplantation

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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