Opportunistic infections of the central nervous system in the transplant patient

Bruce A. Cohen*, Valentina Stosor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Therapeutic advances in transplantation medicine have resulted in ever expanding patient populations that receive organ or stem cell transplantation. Modern potent immunomodulatory therapies have resulted in improvements in allograft and patient survival, but, consequently, as a result of the immunosuppressive state, transplant recipients are highly vulnerable to infection, including those that affect the central nervous system (CNS). CNS infections present a diagnostic and therapeutic challenge for clinicians involved in the care of the transplant patient, with a propensity to result in profound morbidity and often high mortality in this patient population. Here, we review major opportunistic pathogens of the CNS seen in transplant patients, highlighting distinguishing epidemiologic and clinical features.

Original languageEnglish (US)
Article number376
JournalCurrent neurology and neuroscience reports
Volume13
Issue number9
DOIs
StatePublished - Oct 14 2013

Keywords

  • Aspergillus
  • Brain abscess
  • Cerebritis
  • Cryptococcus
  • Cytomegalovirus
  • Encephalitis
  • Epstein-Barr virus
  • Herpes simplex virus
  • Human herpesvirus-6
  • Human herpesvirus-7
  • JC virus
  • Listeria monocytogenes
  • Meningitis
  • Meningoencephalitis
  • Mucormycosis
  • Mycobacterium tuberculosis
  • Myelitis
  • Nervous system infection
  • Nocardia
  • Opportunistic infection
  • Organ transplantation
  • Progressive multifocal leukoencephalopathy
  • Stem cell transplantation
  • Toxoplasma gondii
  • Varicella-zoster virus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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