Optical cochlear implants: Evaluation of surgical approach and laser parameters in cats

Suhrud M. Rajguru; Agnella Izzo Matic; Alan M. Robinson; Andrew J. Fishman; Laura E. Moreno; Allison Bradley; Irena Vujanovic; Joe Breen; Jonathon D. Wells; Mark Bendett; Claus Peter Richter

doi:10.1016/j.heares.2010.06.021

Optical cochlear implants: Evaluation of surgical approach and laser parameters in cats

Suhrud M. Rajguru, Agnella Izzo Matic, Alan M. Robinson, Andrew J. Fishman, Laura E. Moreno, Allison Bradley, Irena Vujanovic, Joe Breen, Jonathon D. Wells, Mark Bendett, Claus Peter Richter^*

^*Corresponding author for this work

Otolaryngology

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Previous research has shown that neural stimulation with infrared radiation (IR) is spatially selective and illustrated the potential of IR in stimulating auditory neurons. The present work demonstrates the application of a miniaturized pulsed IR stimulator for chronic implantation in cats, quantifies its efficacy, and short-term safety in stimulating auditory neurons. IR stimulation of the neurons was achieved using an optical fiber inserted through a cochleostomy drilled in the basal turn of the cat cochlea and was characterized by measuring compound action potentials (CAPs). Neurons were stimulated with IR at various pulse durations, radiant exposures, and pulse repetition rates. Pulse durations as short as 50 μs were successful in evoking CAPs in normal as well as deafened cochleae. Continual stimulation was provided at 200 pulses per second, at 200 mW per pulse, and 100 μs pulse duration. Stable CAP amplitudes were observed for up to 10 h of continual IR stimulation. Combined with histological data, the results suggest that pulsed IR stimulation does not lead to detectable acute tissue damage and validate the stimulation parameters that can be used in future chronic implants based on pulsed IR.

Original language	English (US)
Pages (from-to)	102-111
Number of pages	10
Journal	Hearing research
Volume	269
Issue number	1-2
DOIs	https://doi.org/10.1016/j.heares.2010.06.021
State	Published - Oct 2010

Funding

The care and use of adult cats in this study was carried out in accordance with the NIH Guide for the Care and Use of Laboratory Animals and was approved by the Animal Care and Use Committee of Northwestern University. This work was funded by National Institutes of Health grant 1R41DC008515-02 .

ASJC Scopus subject areas

Sensory Systems

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10.1016/j.heares.2010.06.021

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@article{38f4ebb16b7b4fecaa6b1db892995773,

title = "Optical cochlear implants: Evaluation of surgical approach and laser parameters in cats",

abstract = "Previous research has shown that neural stimulation with infrared radiation (IR) is spatially selective and illustrated the potential of IR in stimulating auditory neurons. The present work demonstrates the application of a miniaturized pulsed IR stimulator for chronic implantation in cats, quantifies its efficacy, and short-term safety in stimulating auditory neurons. IR stimulation of the neurons was achieved using an optical fiber inserted through a cochleostomy drilled in the basal turn of the cat cochlea and was characterized by measuring compound action potentials (CAPs). Neurons were stimulated with IR at various pulse durations, radiant exposures, and pulse repetition rates. Pulse durations as short as 50 μs were successful in evoking CAPs in normal as well as deafened cochleae. Continual stimulation was provided at 200 pulses per second, at 200 mW per pulse, and 100 μs pulse duration. Stable CAP amplitudes were observed for up to 10 h of continual IR stimulation. Combined with histological data, the results suggest that pulsed IR stimulation does not lead to detectable acute tissue damage and validate the stimulation parameters that can be used in future chronic implants based on pulsed IR.",

author = "Rajguru, {Suhrud M.} and Matic, {Agnella Izzo} and Robinson, {Alan M.} and Fishman, {Andrew J.} and Moreno, {Laura E.} and Allison Bradley and Irena Vujanovic and Joe Breen and Wells, {Jonathon D.} and Mark Bendett and Richter, {Claus Peter}",

note = "Funding Information: The care and use of adult cats in this study was carried out in accordance with the NIH Guide for the Care and Use of Laboratory Animals and was approved by the Animal Care and Use Committee of Northwestern University. This work was funded by National Institutes of Health grant 1R41DC008515-02 . ",

year = "2010",

month = oct,

doi = "10.1016/j.heares.2010.06.021",

language = "English (US)",

volume = "269",

pages = "102--111",

journal = "Hearing research",

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T2 - Evaluation of surgical approach and laser parameters in cats

AU - Rajguru, Suhrud M.

AU - Matic, Agnella Izzo

AU - Robinson, Alan M.

AU - Fishman, Andrew J.

AU - Moreno, Laura E.

AU - Bradley, Allison

AU - Vujanovic, Irena

AU - Breen, Joe

AU - Wells, Jonathon D.

AU - Bendett, Mark

AU - Richter, Claus Peter

N1 - Funding Information: The care and use of adult cats in this study was carried out in accordance with the NIH Guide for the Care and Use of Laboratory Animals and was approved by the Animal Care and Use Committee of Northwestern University. This work was funded by National Institutes of Health grant 1R41DC008515-02 .

PY - 2010/10

Y1 - 2010/10

N2 - Previous research has shown that neural stimulation with infrared radiation (IR) is spatially selective and illustrated the potential of IR in stimulating auditory neurons. The present work demonstrates the application of a miniaturized pulsed IR stimulator for chronic implantation in cats, quantifies its efficacy, and short-term safety in stimulating auditory neurons. IR stimulation of the neurons was achieved using an optical fiber inserted through a cochleostomy drilled in the basal turn of the cat cochlea and was characterized by measuring compound action potentials (CAPs). Neurons were stimulated with IR at various pulse durations, radiant exposures, and pulse repetition rates. Pulse durations as short as 50 μs were successful in evoking CAPs in normal as well as deafened cochleae. Continual stimulation was provided at 200 pulses per second, at 200 mW per pulse, and 100 μs pulse duration. Stable CAP amplitudes were observed for up to 10 h of continual IR stimulation. Combined with histological data, the results suggest that pulsed IR stimulation does not lead to detectable acute tissue damage and validate the stimulation parameters that can be used in future chronic implants based on pulsed IR.

AB - Previous research has shown that neural stimulation with infrared radiation (IR) is spatially selective and illustrated the potential of IR in stimulating auditory neurons. The present work demonstrates the application of a miniaturized pulsed IR stimulator for chronic implantation in cats, quantifies its efficacy, and short-term safety in stimulating auditory neurons. IR stimulation of the neurons was achieved using an optical fiber inserted through a cochleostomy drilled in the basal turn of the cat cochlea and was characterized by measuring compound action potentials (CAPs). Neurons were stimulated with IR at various pulse durations, radiant exposures, and pulse repetition rates. Pulse durations as short as 50 μs were successful in evoking CAPs in normal as well as deafened cochleae. Continual stimulation was provided at 200 pulses per second, at 200 mW per pulse, and 100 μs pulse duration. Stable CAP amplitudes were observed for up to 10 h of continual IR stimulation. Combined with histological data, the results suggest that pulsed IR stimulation does not lead to detectable acute tissue damage and validate the stimulation parameters that can be used in future chronic implants based on pulsed IR.

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Optical cochlear implants: Evaluation of surgical approach and laser parameters in cats

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