Optical coherence photoacoustic microscopy: Accomplishing optical coherence tomography and photoacoustic microscopy with a single light source

Xiangyang Zhang, Hao F. Zhang, Shuliang Jiao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We developed optical coherence photoacoustic microscopy (OC-PAM) to demonstrate that the functions of optical coherence tomography (OCT) and photoacoustic microscopy (PAM) can be achieved simultaneously by using a single illuminating light source. We used a pulsed broadband laser centered at 580nm and detected the absorbed photons through photoacoustic detection and the back-scattered photons with an interferometer. In OC-PAM, each laser pulse generates both one OCT A-line and one PAM A-line simultaneously; as a result, the two imaging modalities are intrinsically co-registered in the lateral directions. In vivo images of the mouse ear were acquired to demonstrate the capabilities of OC-PAM.

Original languageEnglish (US)
Article number030502
JournalJournal of Biomedical Optics
Volume17
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • hemoglobin
  • melanin
  • optical coherence tomography
  • photoacoustic image
  • photoacoustic microscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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