Optical cross-sectional imaging of the macula with the retinal thickness analyzer in X-linked retinoschisis

Angelo P. Tanna, Sanjay Asrani, Ran Zeimer*, Shazhou Zou, Morton F. Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: To assess the morphologic characteristics of the foveal abnormality in juvenile X-linked retinoschisis using the scanning retinal thickness analyzer (RTA). This characteristic foveal abnormality is present in 83% to 100% of patients with X-linked retinoschisis and has not been demonstrated histopathologically. Methods: The RTA is a noncontact imaging device. The RTA scans an obliquely oriented slit laser beam across the macula to obtain a series of optical cross sections, which are digitized. Participants: The RTA was used to examine 7 eyes of 5 patients with X-linked retinoschisis. Results: The RTA demonstrated foveal schisis in all eyes examined. In 2 eyes of 2 patients, a single schisis cavity, with an inner leaf in a dome-shaped configuration, was present. In 4 eyes of 3 patients, a single schisis cavity containing fine strands was present. Some of these strands partially, and others completely, bridged the cavity. In 1 eye of 1 patient, 2 separate schisis cavities with bridging strands were present in the fovea. Conclusions: Scanning RTA is a noninvasive imaging modality capable of producing optical cross sections that demonstrate the extent and structural details of the foveal schisis in X-linked retinoschisis. Scanning RTA seems to be effective in the detection, characterization, and quantification of foveal schisis.

Original languageEnglish (US)
Pages (from-to)1036-1041
Number of pages6
JournalArchives of ophthalmology
Issue number8
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Ophthalmology


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