Optical imaging of visually evoked responses in the middle temporal area after deactivation of primary visual cortex in adult primates

Christine E. Collins, Xiangmin Xu, Ilya Khaytin, Peter M. Kaskan, Vivien A. Casagrande, Jon H. Kaas*

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The middle temporal area (MT) is a visual area in primates with direct and indirect inputs from the primary visual cortex (V1), a role in visual motion perception, and a suggested role in "blindsight." When V1 is deactivated, some studies report continued activation of MT neurons, which has been attributed to an indirect pathway to MT from the superior colliculus. Here we used muscimol to deactivate V1 while optically imaging visually evoked activity in MT in two primates, owl monkeys and galagos, where MT is exposed on the brain surface. The partial loss of V1 inputs abolished all or nearly all evoked activity in the retinotopically matched part of MT. Low levels of activation that persisted in portions of MT that were unstimulated or retinotopically congruent with the blocked portion of V1 appeared to reflect the spread of activity from stimulated to unstimulated parts of MT. Thus, a significant pathway based on the superior colliculus was not demonstrated.

Original languageEnglish (US)
Pages (from-to)5594-5599
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number15
DOIs
StatePublished - Apr 12 2005

Keywords

  • Blindsight
  • Intrinsic connections
  • Muscimol
  • V1 lesion

ASJC Scopus subject areas

  • General

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