Optical Mapping of the Sinoatrial Node and Atrioventricular Node

Ajit H. Janardhan*, Di Lang, Igor R. Efimov

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Technological advances often precede scientific breakthroughs that have led to leaps in our understanding of human physiology. The advent of the electrical galvanometer was a landmark advancement that enabled careful study of the electrical activation of the heart. Similarly, optical imaging, or mapping, using fluorescent, voltage sensitive dyes has enabled the careful study of the sinoatrial (SA) and atrioventricular (AV) nodes, and improved our understanding of how anatomic structure is related to electrophysiological function. We review the major findings of optical mapping studies of the sinoatrial node (SAN) and atrioventricular node (AVN), with particular emphasis on clinically relevant physiology and pathophysiology. We pay particular attention to clinical implications of these seminal findings derived from animal models and from the optical mapping study of human hearts. The studies presented are intended to improve the reader's understanding of SAN and AVN physiology, as well as to offer insight into the advantages and limitations of optical mapping

Original languageEnglish (US)
Title of host publicationCardiac Mapping
Subtitle of host publicationFourth Edition
PublisherWiley-Blackwell
Pages79-89
Number of pages11
ISBN (Print)9780470670460
DOIs
StatePublished - Dec 18 2012
Externally publishedYes

Keywords

  • Atrial fibrillation
  • Atrial flutter
  • Atrioventricular node
  • AV node reentry
  • AVN
  • AVNRT
  • Connexin43
  • Cx43
  • Exit block
  • Fast pathway
  • Junctional rhythm
  • SAN
  • Sinoatrial node
  • Slow pathway

ASJC Scopus subject areas

  • Medicine(all)

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