Optical parameter variability in laser nerve stimulation: A study of pulse duration, repetition rate, and wavelength

Agnella D. Izzo; Joseph T. Walsh; E. Duco Jansen; Mark Bendett; Jim Webb; Heather Ralph; Claus Peter Richter

doi:10.1109/TBME.2007.892925

Optical parameter variability in laser nerve stimulation: A study of pulse duration, repetition rate, and wavelength

Agnella D. Izzo^*, Joseph T. Walsh, E. Duco Jansen, Mark Bendett, Jim Webb, Heather Ralph, Claus Peter Richter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Pulsed lasers can evoke neural activity from motor as well as sensory neurons in vivo. Lasers allow more selective spatial resolution of stimulation than the conventional electrical stimulation. To date, few studies have examined pulsed, mid-infrared laser stimulation of nerves and very little of the available optical parameter space has been studied. In this study, a pulsed diode laser, with wavelength between 1.844-1.873 μm, was used to elicit compound action potentials (CAPs) from the auditory system of the gerbil. We found that pulse durations as short as 35 μs elicit a CAP from the cochlea. In addition, repetition rates up to 13 Hz can continually stimulate cochlear spiral ganglion cells for extended periods of time. Varying the wavelength and, therefore, the optical penetration depth, allowed different populations of neurons to be stimulated. The technology of optical stimulation could significantly improve cochlear implants, which are hampered by a lack of spatial selectivity.

Original language	English (US)
Pages (from-to)	1108-1114
Number of pages	7
Journal	IEEE Transactions on Biomedical Engineering
Volume	54
Issue number	6
DOIs	https://doi.org/10.1109/TBME.2007.892925
State	Published - Jun 2007

Funding

Manuscript received June 30, 2006; revised November 20, 2006. This work was supported in part by the ER Capita Foundation and in part by the National Institutes of Health (NIH) under Grant F31 DC008246-01, Grant R41 DC008515-01, and Grant HHN-260-2006-00006-C. Asterisk indicates corresponding author. *A. D. Izzo is with the Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 USA. She is also with the Department of Otolaryngology, Feinberg Medical School, Northwestern University, Chicago, IL 60611 USA (e-mail: [email protected]).

Keywords

Auditory nerve
Cochlear implant
Spiral ganglion cell

ASJC Scopus subject areas

Biomedical Engineering

Access to Document

10.1109/TBME.2007.892925

Cite this

@article{142eaa43359541ed8c21026f69638458,

title = "Optical parameter variability in laser nerve stimulation: A study of pulse duration, repetition rate, and wavelength",

abstract = "Pulsed lasers can evoke neural activity from motor as well as sensory neurons in vivo. Lasers allow more selective spatial resolution of stimulation than the conventional electrical stimulation. To date, few studies have examined pulsed, mid-infrared laser stimulation of nerves and very little of the available optical parameter space has been studied. In this study, a pulsed diode laser, with wavelength between 1.844-1.873 μm, was used to elicit compound action potentials (CAPs) from the auditory system of the gerbil. We found that pulse durations as short as 35 μs elicit a CAP from the cochlea. In addition, repetition rates up to 13 Hz can continually stimulate cochlear spiral ganglion cells for extended periods of time. Varying the wavelength and, therefore, the optical penetration depth, allowed different populations of neurons to be stimulated. The technology of optical stimulation could significantly improve cochlear implants, which are hampered by a lack of spatial selectivity.",

keywords = "Auditory nerve, Cochlear implant, Spiral ganglion cell",

author = "Izzo, {Agnella D.} and Walsh, {Joseph T.} and Jansen, {E. Duco} and Mark Bendett and Jim Webb and Heather Ralph and Richter, {Claus Peter}",

note = "Funding Information: Manuscript received June 30, 2006; revised November 20, 2006. This work was supported in part by the ER Capita Foundation and in part by the National Institutes of Health (NIH) under Grant F31 DC008246-01, Grant R41 DC008515-01, and Grant HHN-260-2006-00006-C. Asterisk indicates corresponding author. *A. D. Izzo is with the Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 USA. She is also with the Department of Otolaryngology, Feinberg Medical School, Northwestern University, Chicago, IL 60611 USA (e-mail: [email protected]).",

year = "2007",

month = jun,

doi = "10.1109/TBME.2007.892925",

language = "English (US)",

volume = "54",

pages = "1108--1114",

journal = "IEEE Transactions on Biomedical Engineering",

issn = "0018-9294",

publisher = "IEEE Computer Society",

number = "6",

}

TY - JOUR

T1 - Optical parameter variability in laser nerve stimulation

T2 - A study of pulse duration, repetition rate, and wavelength

AU - Izzo, Agnella D.

AU - Walsh, Joseph T.

AU - Jansen, E. Duco

AU - Bendett, Mark

AU - Webb, Jim

AU - Ralph, Heather

AU - Richter, Claus Peter

N1 - Funding Information: Manuscript received June 30, 2006; revised November 20, 2006. This work was supported in part by the ER Capita Foundation and in part by the National Institutes of Health (NIH) under Grant F31 DC008246-01, Grant R41 DC008515-01, and Grant HHN-260-2006-00006-C. Asterisk indicates corresponding author. *A. D. Izzo is with the Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 USA. She is also with the Department of Otolaryngology, Feinberg Medical School, Northwestern University, Chicago, IL 60611 USA (e-mail: [email protected]).

PY - 2007/6

Y1 - 2007/6

N2 - Pulsed lasers can evoke neural activity from motor as well as sensory neurons in vivo. Lasers allow more selective spatial resolution of stimulation than the conventional electrical stimulation. To date, few studies have examined pulsed, mid-infrared laser stimulation of nerves and very little of the available optical parameter space has been studied. In this study, a pulsed diode laser, with wavelength between 1.844-1.873 μm, was used to elicit compound action potentials (CAPs) from the auditory system of the gerbil. We found that pulse durations as short as 35 μs elicit a CAP from the cochlea. In addition, repetition rates up to 13 Hz can continually stimulate cochlear spiral ganglion cells for extended periods of time. Varying the wavelength and, therefore, the optical penetration depth, allowed different populations of neurons to be stimulated. The technology of optical stimulation could significantly improve cochlear implants, which are hampered by a lack of spatial selectivity.

AB - Pulsed lasers can evoke neural activity from motor as well as sensory neurons in vivo. Lasers allow more selective spatial resolution of stimulation than the conventional electrical stimulation. To date, few studies have examined pulsed, mid-infrared laser stimulation of nerves and very little of the available optical parameter space has been studied. In this study, a pulsed diode laser, with wavelength between 1.844-1.873 μm, was used to elicit compound action potentials (CAPs) from the auditory system of the gerbil. We found that pulse durations as short as 35 μs elicit a CAP from the cochlea. In addition, repetition rates up to 13 Hz can continually stimulate cochlear spiral ganglion cells for extended periods of time. Varying the wavelength and, therefore, the optical penetration depth, allowed different populations of neurons to be stimulated. The technology of optical stimulation could significantly improve cochlear implants, which are hampered by a lack of spatial selectivity.

KW - Auditory nerve

KW - Cochlear implant

KW - Spiral ganglion cell

UR - http://www.scopus.com/inward/record.url?scp=34249307490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249307490&partnerID=8YFLogxK

U2 - 10.1109/TBME.2007.892925

DO - 10.1109/TBME.2007.892925

M3 - Article

C2 - 17554829

AN - SCOPUS:34249307490

SN - 0018-9294

VL - 54

SP - 1108

EP - 1114

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

IS - 6

ER -

Optical parameter variability in laser nerve stimulation: A study of pulse duration, repetition rate, and wavelength

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this