Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries

Konstantin Maslov, Hao F. Zhang, Song Hu, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

691 Scopus citations


Capillaries, the smallest blood vessels, are the distal end of the vasculature where oxygen and nutrients are exchanged between blood and tissue. Hence, noninvasive imaging of capillaries and function in vivo has long been desired as a window to studying fundamental physiology, such as neurovascular coupling. Existing imaging modalities cannot provide the required sensitivity and spatial resolution. We present in vivo imaging of the microvasculature including single capillaries in mice using optical-resolution photoacoustic microscopy (OR-PAM) developed in our laboratory. OR-PAM provides a lateral resolution of 5 μm and an imaging depth >0.7 mm.

Original languageEnglish (US)
Pages (from-to)929-931
Number of pages3
JournalOptics Letters
Issue number9
StatePublished - May 1 2008

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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