Optical sensing of biomolecules using microring resonators

Ayça Yalçin; Ketul C. Popat; John C. Aldridge; Tejal A. Desai; John Hryniewicz; Nabil Chbouki; Brent E. Little; Oliver King; Vien Van; Sai Chu; David Gill; Matthew Anthes-Washburn; M. Selim Ünlü; Bennett B. Goldberg

doi:10.1109/JSTQE.2005.863003

Optical sensing of biomolecules using microring resonators

Ayça Yalçin^*, Ketul C. Popat, John C. Aldridge, Tejal A. Desai, John Hryniewicz, Nabil Chbouki, Brent E. Little, Oliver King, Vien Van, Sai Chu, David Gill, Matthew Anthes-Washburn, M. Selim Ünlü, Bennett B. Goldberg

^*Corresponding author for this work

Physics and Astronomy

Research output: Contribution to journal › Article › peer-review

361 Scopus citations

Abstract

A biosensor application of vertically coupled glass microring resonators with Q ∼ 12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus high sensitivity to refractive index changes (limit of detection of 1.8 × 10^-5 refractive index units), are achieved. Ellipsometry and X-ray photoelectron spectroscopy results indicate successful modification of biosensor surfaces. Experimental data obtained separately for a bulk change of refractive index of the medium and for avidin-biotin binding on the ring surface are reported. Excellent repeatability and close-to-complete surface regeneration after binding are experimentally demonstrated.

Original language	English (US)
Pages (from-to)	148-154
Number of pages	7
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	12
Issue number	1
DOIs	https://doi.org/10.1109/JSTQE.2005.863003
State	Published - Jan 2006

Keywords

Biomedical transducer
Cavity resonator
Circular waveguide

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1109/JSTQE.2005.863003

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Yalçin, A., Popat, K. C., Aldridge, J. C., Desai, T. A., Hryniewicz, J., Chbouki, N., Little, B. E., King, O., Van, V., Chu, S., Gill, D., Anthes-Washburn, M., Ünlü, M. S., & Goldberg, B. B. (2006). Optical sensing of biomolecules using microring resonators. IEEE Journal on Selected Topics in Quantum Electronics, 12(1), 148-154. https://doi.org/10.1109/JSTQE.2005.863003

@article{02e4beec0d9a4ec7af8898d240f78b46,

title = "Optical sensing of biomolecules using microring resonators",

abstract = "A biosensor application of vertically coupled glass microring resonators with Q ∼ 12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus high sensitivity to refractive index changes (limit of detection of 1.8 × 10-5 refractive index units), are achieved. Ellipsometry and X-ray photoelectron spectroscopy results indicate successful modification of biosensor surfaces. Experimental data obtained separately for a bulk change of refractive index of the medium and for avidin-biotin binding on the ring surface are reported. Excellent repeatability and close-to-complete surface regeneration after binding are experimentally demonstrated.",

keywords = "Biomedical transducer, Cavity resonator, Circular waveguide",

author = "Ay{\c c}a Yal{\c c}in and Popat, {Ketul C.} and Aldridge, {John C.} and Desai, {Tejal A.} and John Hryniewicz and Nabil Chbouki and Little, {Brent E.} and Oliver King and Vien Van and Sai Chu and David Gill and Matthew Anthes-Washburn and {\"U}nl{\"u}, {M. Selim} and Goldberg, {Bennett B.}",

note = "Funding Information: Manuscript received February 24, 2005; revised September 29, 2005. This work was supported in part by the Army Research Laboratory (ARL) and was accomplished under the AMCAC-RTP Cooperative Agreement DAAD19-00-2-0004. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon.",

year = "2006",

month = jan,

doi = "10.1109/JSTQE.2005.863003",

language = "English (US)",

volume = "12",

pages = "148--154",

journal = "IEEE Journal on Selected Topics in Quantum Electronics",

issn = "1077-260X",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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T1 - Optical sensing of biomolecules using microring resonators

AU - Yalçin, Ayça

AU - Popat, Ketul C.

AU - Aldridge, John C.

AU - Desai, Tejal A.

AU - Hryniewicz, John

AU - Chbouki, Nabil

AU - Little, Brent E.

AU - King, Oliver

AU - Van, Vien

AU - Chu, Sai

AU - Gill, David

AU - Anthes-Washburn, Matthew

AU - Ünlü, M. Selim

AU - Goldberg, Bennett B.

N1 - Funding Information: Manuscript received February 24, 2005; revised September 29, 2005. This work was supported in part by the Army Research Laboratory (ARL) and was accomplished under the AMCAC-RTP Cooperative Agreement DAAD19-00-2-0004. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon.

PY - 2006/1

Y1 - 2006/1

N2 - A biosensor application of vertically coupled glass microring resonators with Q ∼ 12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus high sensitivity to refractive index changes (limit of detection of 1.8 × 10-5 refractive index units), are achieved. Ellipsometry and X-ray photoelectron spectroscopy results indicate successful modification of biosensor surfaces. Experimental data obtained separately for a bulk change of refractive index of the medium and for avidin-biotin binding on the ring surface are reported. Excellent repeatability and close-to-complete surface regeneration after binding are experimentally demonstrated.

AB - A biosensor application of vertically coupled glass microring resonators with Q ∼ 12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus high sensitivity to refractive index changes (limit of detection of 1.8 × 10-5 refractive index units), are achieved. Ellipsometry and X-ray photoelectron spectroscopy results indicate successful modification of biosensor surfaces. Experimental data obtained separately for a bulk change of refractive index of the medium and for avidin-biotin binding on the ring surface are reported. Excellent repeatability and close-to-complete surface regeneration after binding are experimentally demonstrated.

KW - Biomedical transducer

KW - Cavity resonator

KW - Circular waveguide

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JO - IEEE Journal on Selected Topics in Quantum Electronics

JF - IEEE Journal on Selected Topics in Quantum Electronics

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Optical sensing of biomolecules using microring resonators

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