Optical sensing of biomolecules using microring resonators

Ayça Yalçin*, Ketul C. Popat, John C. Aldridge, Tejal A. Desai, John Hryniewicz, Nabil Chbouki, Brent E. Little, Oliver King, Vien Van, Sai Chu, David Gill, Matthew Anthes-Washburn, M. Selim Ünlü, Bennett B. Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

361 Scopus citations


A biosensor application of vertically coupled glass microring resonators with Q ∼ 12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus high sensitivity to refractive index changes (limit of detection of 1.8 × 10-5 refractive index units), are achieved. Ellipsometry and X-ray photoelectron spectroscopy results indicate successful modification of biosensor surfaces. Experimental data obtained separately for a bulk change of refractive index of the medium and for avidin-biotin binding on the ring surface are reported. Excellent repeatability and close-to-complete surface regeneration after binding are experimentally demonstrated.

Original languageEnglish (US)
Pages (from-to)148-154
Number of pages7
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number1
StatePublished - Jan 2006


  • Biomedical transducer
  • Cavity resonator
  • Circular waveguide

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


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