Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabels

Kun Chen, Yang Liu, Guillermo Ameer, Vadim Backman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Optical molecular imaging could potentially enable noninvasive high-resolution characterization and diagnosis of living tissue. The capability to image multiple molecular targets simultaneously is particularly important. Currently this task cannot be achieved using conventional optical contrast agents, due to their broad spectral responses (;80 to 200 nm). Developments in research on semiconductor nanocrystals (quantum dots) provide one possible solution. We describe a different concept of multilabel molecular imaging that utilizes resonant light-scattering spectroscopy of multilayered nanospheres to achieve tunable ultrasharp resonance peaks with widths as narrow as 10 nm. Our theoretical study demonstrates that dozens of molecular targets can potentially be imaged simultaneously using this approach.

Original languageEnglish (US)
Article number024005
JournalJournal of Biomedical Optics
Volume10
Issue number2
DOIs
StatePublished - Mar 2005

Keywords

  • Multilabel molecular imaging
  • Multilayered nanospheres
  • Resonant lightscattering spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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