Optimal phase-tracking of the nonlinear circadian oscillator

Neda Bagheri*, Jörg Stelling, Francis J. Doyle

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

13 Scopus citations


Through investigation of transient phase characteristics, a methodology is developed to optimize the phase resetting properties of robust nonlinear biological oscillators; in particular, those of the circadian rhythm. This pacemaker is an autonomous chemical oscillator with a period close to 24 hours. Research in chronobiology indicates that light stimuli can be used to delay or advance the phase of the oscillator, allowing it to synchronize physiological processes and govern daily fluctuations in the core body. This paper proves that a circadian oscillator optimally recovers extreme phase difference (half the nominal period) within 4-days.

Original languageEnglish (US)
Pages (from-to)3235-3240
Number of pages6
JournalProceedings of the American Control Conference
StatePublished - Sep 2 2005
Event2005 American Control Conference, ACC - Portland, OR, United States
Duration: Jun 8 2005Jun 10 2005

ASJC Scopus subject areas

  • Electrical and Electronic Engineering


Dive into the research topics of 'Optimal phase-tracking of the nonlinear circadian oscillator'. Together they form a unique fingerprint.

Cite this