Optimal Voltage and Electrical Pulse Conditions for Electrical Ablation to Induce Immunogenic Cell Death (ICD)

Eun Jin Go; Dasom Yang; Won Hyoung Ryu; Hong Jae Chon; Chan Kim; Kyung Soon Park; Dong Hyun Kim; Dong Keun Han; Wooram Park

doi:10.1016/j.jiec.2020.10.038

Optimal Voltage and Electrical Pulse Conditions for Electrical Ablation to Induce Immunogenic Cell Death (ICD)

Eun Jin Go, Dasom Yang, Won Hyoung Ryu, Hong Jae Chon, Chan Kim, Kyung Soon Park, Dong Hyun Kim, Dong Keun Han^*, Wooram Park

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Electrical ablation (EA) is a non-thermal ablation technique that causes less damage to the tissue surrounding the targeted area than conventional thermal ablation. EA induces immunogenic cell death (ICD) and can potentially synergize with cancer immunotherapy. In this study, the optimal voltage and pulse conditions for the induction of ICD were identified. Finite element analysis was used to estimate the ablation zone under a variety of voltage and pulse conditions. Cancer cells were cultured in vitro under two- and three-dimensional conditions to assess cell viability under different voltage and pulse conditions. Additionally, the expression of damage-associated molecular pattern (DAMP) markers of ICD was measured to identify an optimal voltage condition. Tumor volume, body weight, and survival after EA treatment were measured in vivo to identify the optimal pulse conditions. The optimal conditions to induce ICD by EA identified in this study are suitable to be combined with cancer immunotherapy.

Original language	English (US)
Pages (from-to)	225-232
Number of pages	8
Journal	Journal of Industrial and Engineering Chemistry
Volume	94
DOIs	https://doi.org/10.1016/j.jiec.2020.10.038
State	Published - Feb 25 2021

Funding

This work was supported by the National Research Foundation (NRF) of Korea. The grant was funded by the Ministry of Science and ICT (MSIT), Republic of Korea ( 2018R1C1B6001120 , 2019R1A6A1A03032888 , 2020M2D9A3094208 , and 2020R1A2B5B03002344 ).

Keywords

Cancer immunotherapy
Damage-associated molecular pattern molecules
Electrical ablation
Immunogenic cell death
Tumor ablation

ASJC Scopus subject areas

General Chemical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiec.2020.10.038

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title = "Optimal Voltage and Electrical Pulse Conditions for Electrical Ablation to Induce Immunogenic Cell Death (ICD)",

abstract = "Electrical ablation (EA) is a non-thermal ablation technique that causes less damage to the tissue surrounding the targeted area than conventional thermal ablation. EA induces immunogenic cell death (ICD) and can potentially synergize with cancer immunotherapy. In this study, the optimal voltage and pulse conditions for the induction of ICD were identified. Finite element analysis was used to estimate the ablation zone under a variety of voltage and pulse conditions. Cancer cells were cultured in vitro under two- and three-dimensional conditions to assess cell viability under different voltage and pulse conditions. Additionally, the expression of damage-associated molecular pattern (DAMP) markers of ICD was measured to identify an optimal voltage condition. Tumor volume, body weight, and survival after EA treatment were measured in vivo to identify the optimal pulse conditions. The optimal conditions to induce ICD by EA identified in this study are suitable to be combined with cancer immunotherapy.",

keywords = "Cancer immunotherapy, Damage-associated molecular pattern molecules, Electrical ablation, Immunogenic cell death, Tumor ablation",

author = "Go, {Eun Jin} and Dasom Yang and Ryu, {Won Hyoung} and Chon, {Hong Jae} and Chan Kim and Park, {Kyung Soon} and Kim, {Dong Hyun} and Han, {Dong Keun} and Wooram Park",

note = "Publisher Copyright: {\textcopyright} 2020 The Korean Society of Industrial and Engineering Chemistry",

year = "2021",

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doi = "10.1016/j.jiec.2020.10.038",

language = "English (US)",

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AU - Go, Eun Jin

AU - Yang, Dasom

AU - Ryu, Won Hyoung

AU - Chon, Hong Jae

AU - Kim, Chan

AU - Park, Kyung Soon

AU - Kim, Dong Hyun

AU - Han, Dong Keun

AU - Park, Wooram

PY - 2021/2/25

Y1 - 2021/2/25

N2 - Electrical ablation (EA) is a non-thermal ablation technique that causes less damage to the tissue surrounding the targeted area than conventional thermal ablation. EA induces immunogenic cell death (ICD) and can potentially synergize with cancer immunotherapy. In this study, the optimal voltage and pulse conditions for the induction of ICD were identified. Finite element analysis was used to estimate the ablation zone under a variety of voltage and pulse conditions. Cancer cells were cultured in vitro under two- and three-dimensional conditions to assess cell viability under different voltage and pulse conditions. Additionally, the expression of damage-associated molecular pattern (DAMP) markers of ICD was measured to identify an optimal voltage condition. Tumor volume, body weight, and survival after EA treatment were measured in vivo to identify the optimal pulse conditions. The optimal conditions to induce ICD by EA identified in this study are suitable to be combined with cancer immunotherapy.

AB - Electrical ablation (EA) is a non-thermal ablation technique that causes less damage to the tissue surrounding the targeted area than conventional thermal ablation. EA induces immunogenic cell death (ICD) and can potentially synergize with cancer immunotherapy. In this study, the optimal voltage and pulse conditions for the induction of ICD were identified. Finite element analysis was used to estimate the ablation zone under a variety of voltage and pulse conditions. Cancer cells were cultured in vitro under two- and three-dimensional conditions to assess cell viability under different voltage and pulse conditions. Additionally, the expression of damage-associated molecular pattern (DAMP) markers of ICD was measured to identify an optimal voltage condition. Tumor volume, body weight, and survival after EA treatment were measured in vivo to identify the optimal pulse conditions. The optimal conditions to induce ICD by EA identified in this study are suitable to be combined with cancer immunotherapy.

KW - Cancer immunotherapy

KW - Damage-associated molecular pattern molecules

KW - Electrical ablation

KW - Immunogenic cell death

KW - Tumor ablation

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Optimal Voltage and Electrical Pulse Conditions for Electrical Ablation to Induce Immunogenic Cell Death (ICD)

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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