TY - JOUR
T1 - Optimism and Lipid Profiles in Midlife
T2 - A 15-Year Study of Black and White Adults
AU - Qureshi, Farah
AU - Soo, Jackie
AU - Chen, Ying
AU - Roy, Brita
AU - Lloyd-Jones, Donald M.
AU - Kubzansky, Laura D.
AU - Boehm, Julia K.
N1 - Funding Information:
This study was supported by the NIH National Institute on Aging (R03AG046342). FQ was supported by a training grant from NIH ( T32 CA 009001 ) and LDK was supported by the Lee Kum Sheung Center for Health and Happiness . The Coronary Artery Risk Development in Young Adults study is conducted and supported by the NIH National Heart, Lung, and Blood Institute in collaboration with the University of Alabama at Birmingham (HHSN268201800005I and HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). This manuscript has been reviewed by Coronary Artery Risk Development in Young Adults for scientific content.
Publisher Copyright:
© 2021 American Journal of Preventive Medicine
PY - 2022/3
Y1 - 2022/3
N2 - Introduction: Optimism is associated with better cardiovascular health, yet little is known about the underlying mechanisms and whether protective relationships are consistently observed across diverse groups. This study examines optimism's association with lipid profiles over time and separately among Black and White men and women. Methods: Data were from 3,206 middle-aged adults in the Coronary Artery Risk Development in Young Adults study. Optimism was measured in 2000–2001 using the Revised Life Orientation Test. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol measurements were obtained at 5-year intervals through 2015–2016. Linear mixed models evaluated relationships between optimism and lipids, adjusting for covariates, including prebaseline lipids. Subgroup differences were examined using interaction terms and stratification. All analyses were conducted in 2020. Results: Higher optimism was associated with both lower baseline total cholesterol (β= −2.33, 95% CI= −4.31, −0.36) and low-density lipoprotein cholesterol levels (β= −1.93, 95% CI= −3.65, −0.21) and a more rapid incremental increase in both markers over time (total cholesterol: β=0.09, 95% CI=0.00, 0.18; low-density lipoprotein cholesterol: β=0.09, 95% CI=0.01, 0.16). No associations were apparent with baseline triglycerides, high-density lipoprotein cholesterol, or changes in either lipid over time. Tests for interaction only found evidence of heterogeneous associations with baseline triglyceride levels, but stratified models hinted at stronger protective associations with baseline levels of total cholesterol and low-density lipoprotein cholesterol among White women. Conclusions: Optimism may help diverse individuals establish healthy total cholesterol and low-density lipoprotein cholesterol levels before midlife. Although associations were largely consistent across subgroups, stronger associations among White men and White women highlight a need to study optimism's health impact in diverse samples.
AB - Introduction: Optimism is associated with better cardiovascular health, yet little is known about the underlying mechanisms and whether protective relationships are consistently observed across diverse groups. This study examines optimism's association with lipid profiles over time and separately among Black and White men and women. Methods: Data were from 3,206 middle-aged adults in the Coronary Artery Risk Development in Young Adults study. Optimism was measured in 2000–2001 using the Revised Life Orientation Test. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol measurements were obtained at 5-year intervals through 2015–2016. Linear mixed models evaluated relationships between optimism and lipids, adjusting for covariates, including prebaseline lipids. Subgroup differences were examined using interaction terms and stratification. All analyses were conducted in 2020. Results: Higher optimism was associated with both lower baseline total cholesterol (β= −2.33, 95% CI= −4.31, −0.36) and low-density lipoprotein cholesterol levels (β= −1.93, 95% CI= −3.65, −0.21) and a more rapid incremental increase in both markers over time (total cholesterol: β=0.09, 95% CI=0.00, 0.18; low-density lipoprotein cholesterol: β=0.09, 95% CI=0.01, 0.16). No associations were apparent with baseline triglycerides, high-density lipoprotein cholesterol, or changes in either lipid over time. Tests for interaction only found evidence of heterogeneous associations with baseline triglyceride levels, but stratified models hinted at stronger protective associations with baseline levels of total cholesterol and low-density lipoprotein cholesterol among White women. Conclusions: Optimism may help diverse individuals establish healthy total cholesterol and low-density lipoprotein cholesterol levels before midlife. Although associations were largely consistent across subgroups, stronger associations among White men and White women highlight a need to study optimism's health impact in diverse samples.
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U2 - 10.1016/j.amepre.2021.09.011
DO - 10.1016/j.amepre.2021.09.011
M3 - Article
C2 - 35067361
AN - SCOPUS:85123206695
VL - 62
SP - e169-e177
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
SN - 0749-3797
IS - 3
ER -
