Abstract
Adolescent and young adult cancer survivors (AYAs) experience clinically significant distress and have limited access to supportive care services. Interventions to enhance psychological well-being have improved positive affect and reduced depression in clinical and healthy populations and have not been routinely tested in AYA survivors. We are optimizing a web-based positive skills intervention for AYA cancer survivors called Enhancing Management of Psychological Outcomes With Emotion Regulation (EMPOWER) by: (1) determining which intervention components have the strongest effects on well-being and (2) identifying demographic and individual difference variables that mediate and moderate EMPOWER's efficacy. EMPOWER is a five-session online intervention that teaches behavioral and cognitive skills for increasing psychological well-being. Guided by the Multiphase Optimization Strategy (MOST), we assign two levels (yes, no) to each of five intervention components (positive events, capitalizing, & gratitude; mindfulness; positive reappraisal; personal strengths & goal-setting; acts of kindness), allowing us to evaluate the effects of individual and combined intervention components on positive affect in a full factorial design. Post-treatment AYA cancer survivors (N = 352) are recruited from participating NCI-designated comprehensive cancer centers and randomized to one of 32 experimental conditions. Our primary outcome is positive affect; potential mediating and moderating variables include coping self-efficacy and emotional support, respectively. Upon trial completion, we will have an optimized, digital health intervention to enhance psychological well-being among AYA cancer survivors. EMPOWER will be scalable and primed for a large, multi-site trial among AYAs who would otherwise not have access to supportive care interventions to manage distress and enhance well-being.
Original language | English (US) |
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Article number | 107783 |
Journal | Contemporary Clinical Trials |
Volume | 149 |
DOIs | |
State | Published - Feb 2025 |
Funding
This project is supported by the National Cancer Institute of the National Institutes of Health under award number R01CA242849 and is registered on ClinicalTrials.gov (NCT04317417). The study procedures described are approved by the Wake Forest University School of Medicine Institutional Review Board and, through reliance agreements, the Northwestern University and MD Anderson Institutional Review Boards.Funding for this study was supported by the National Cancer Institute of the National Institutes of Health under award number R01CA242849. Dr. Murphy was supported by a grant from National Cancer Institute (K99/R00CA248701) during the preparation of this manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors wish to acknowledge the support of the Atrium Health Wake Forest Baptist Comprehensive Cancer Center Biostatistics Shared Resource, supported by the National Cancer Institute's Cancer Center Support Grant award number P30CA012197 and to acknowledge support through NUCATS, funded in part by a Clinical and Translational Science Award (CTSA) grant from the National Institutes of Health, UL1TR001422. Funding for this study was supported by the National Cancer Institute of the National Institutes of Health under award number R01CA242849 . Dr. Murphy was supported by a grant from National Cancer Institute ( K99/R00CA248701 ) during the preparation of this manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors wish to acknowledge the support of the Atrium Health Wake Forest Baptist Comprehensive Cancer Center Biostatistics Shared Resource, supported by the National Cancer Institute's Cancer Center Support Grant award number P30CA012197 and to acknowledge support through NUCATS, funded in part by a Clinical and Translational Science Award (CTSA) grant from the National Institutes of Health, UL1TR001422 .
Keywords
- Adolescent & young adult
- Cancer
- Factorial design
- Psychosocial
- Well-being
ASJC Scopus subject areas
- Pharmacology (medical)