Optimization of a microfluidic chip for the biobarcode assay

Edgar D. Goluch, Jwa Min Nam, Savka I. Stoeva, Dimitra G. Georganopoulou, Kashan A. Shaikh, Kee Suk Ryu, Thomas N. Chiesl, Annelise E. Barron, Chad A. Mirkin, Chang Liu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate in this work the successful application of functionalized gold nanoparticles and magnetic microparticles in the development of an integrated lab-on-achip- system. By employing the BioBarCode Assay, we have shown that it is possible to quantitatively identify ultra-low concentrations of proteins not only in buffer solutions, but also in serum samples using a microfluidic device. Furthermore, we have developed a method using microarrayed DNA patterns inside the microfluidic channels that will make possible multiplexed detection of biomarkers in a single experiment.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1246-1248
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

Keywords

  • Biobarcode assay
  • Multiplexing
  • Nanoparticles
  • Protein detection

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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