Optimization of a noncanonical anti-infective: Interrogation of the target binding pocket for a small-molecule inhibitor of Escherichia coli polysaccharide capsule expression

Keyphrases

• Non-canonical 100%
• Small Molecule Inhibitors 100%
• Escherichia Coli 100%
• Binding Pocket 100%
• Anti-infective 100%
• Target Binding 100%
• Polysaccharide Capsule 100%
• MPRα 100%
• Salicylate 30%
• 2,4-dinitrophenol 30%
• Binding Site 20%
• Low Affinity 20%
• Isothermal Titration Calorimetry 20%
• Binding Isotherm 20%
• Antibiotic Resistance 10%
• Transcriptional Repressor 10%
• Two-site 10%
• DNA-binding Domain 10%
• Conformational Change 10%
• Biogenesis 10%
• Novel Interactions 10%
• One-site 10%
• Hydrogen-deuterium Exchange Mass Spectrometry 10%
• Single Point 10%
• Point mutant 10%
• Binding Reaction 10%
• Multidrug Efflux Pump 10%
• MarR Family 10%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Polysaccharide 100%
• Binding Site 100%
• Escherichia coli 100%
• Conformation 50%
• Conformational Change 50%
• DNA-binding Domain 50%
• Transcriptional Repressor 50%
• Dynamics 50%
• Hydrogen/Deuterium Exchange Mass Spectrometry 50%
• Biogenesis 50%
• Antibiotic Resistance 50%

Immunology and Microbiology

• Escherichia coli 100%
• Binding Site 100%
• Conformational Transition 50%
• Antimicrobial Resistance 50%
• Dynamics 50%
• Repressor Gene 50%
• Conformation 50%
• DNA Binding 50%
• Biogenesis 50%
• Hydrogen/Deuterium Exchange Mass Spectrometry 50%