Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold

Keyphrases

• Blood-brain Barrier 100%
• Neuronal Nitric Oxide Synthase Inhibitor 100%
• 2-aminopyridine 100%
• Blood-brain Barrier Permeability 100%
• Therapeutic Agents 50%
• Neurodegenerative Diseases 50%
• Human Brain 50%
• New Drugs 50%
• Drug Development 50%
• Caco-2 50%
• Amino Group 50%
• Nitric Oxide Synthase Inhibition 50%
• Neuronal Nitric Oxide Synthase (nNOS) 50%
• Protein Substrate 50%
• Challenging Tasks 50%
• Drug Transporters 50%
• Efficient Delivery 50%
• New Inhibitors 50%
• New Analogs 50%
• Blood-brain Barrier Penetration 50%
• Lipophilicity 50%
• P-glycoprotein (P-gp) 50%
• Central Nervous System Drugs 50%
• Breast Cancer Resistance Protein 50%
• Nitric Oxide Synthase Isoforms 50%
• Inhibitor Potency 50%
• Inhibitor Selectivity 50%
• Passive Permeability 50%
• Efflux Ratio 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Nitric Oxide Synthase Inhibitor 100%
• Neuronal Nitric Oxide Synthase 100%
• 2 Aminopyridine 100%
• Blood-Brain Barrier 100%
• Effusion 50%
• Lipophilicity 25%
• P-Glycoprotein 25%
• Central Nervous System Drug 25%
• Drug Development 25%
• Breast Cancer 25%
• Nitric Oxide Synthase 25%
• Degenerative Disease 25%