Optimizing Toxic Chemical Removal through Defect-Induced UiO-66-NH2 Metal–Organic Framework

Gregory W. Peterson*, Matthew R. Destefano, Sergio J. Garibay, Ann Ploskonka, Monica McEntee, Morgan Hall, Christopher J. Karwacki, Joseph T. Hupp, Omar K. Farha

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


For the first time, an increasing number of defects were introduced to the metal–organic framework UiO-66-NH2 in an attempt to understand the structure–activity trade-offs associated with toxic chemical removal. It was found that an optimum exists with moderate defects for toxic chemicals that react with the linker, whereas those that require hydrolysis at the secondary building unit performed better when more defects were introduced. The insights obtained through this work highlight the ability to dial-in appropriate material formulations, even within the same parent metal–organic framework, allowing for trade-offs between reaction efficiency and mass transfer.

Original languageEnglish (US)
Pages (from-to)15913-15916
Number of pages4
JournalChemistry - A European Journal
Issue number63
StatePublished - Nov 13 2017


  • adsorption
  • chemical warfare agents
  • defects
  • metal–organic frameworks
  • toxic chemicals

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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