Oral manifestations of hematologic and nutritional diseases

Bethanee J. Schlosser, Megan Pirigyi, Ginat W. Mirowski*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Oral manifestations of hematologic and nutritional deficiencies can affect the mucous membranes, teeth, periodontal tissues, salivary glands, and perioral skin. This article reviews common oral manifestations of hematologic conditions starting with disorders of the white blood cells including cyclic hematopoiesis (cyclic neutropenia), leukemias, lymphomas, plasma cell dyscrasias, and mast cell disorders; this is followed by a discussion of the impact of red blood cell disorders including anemias and less common red blood cell dyscrasias (sickle cell disease, hemochromatosis, and congenital erythropoietic porphyria) as well as thrombocytopenia. Several nutritional deficiencies exhibit oral manifestations. The authors specifically discuss the impact of water-soluble vitamins (B2, B3, B6, B9, B12, and C), fat-soluble vitamins (A, D, and K) and the eating disorders anorexia nervosa and bulimia nervosa on the oral mucosa.

Original languageEnglish (US)
Pages (from-to)183-203
Number of pages21
JournalOtolaryngologic Clinics of North America
Issue number1
StatePublished - Feb 2011


  • Amyloidosis
  • Anemia
  • Anorexia
  • Bulimia
  • Glossitis
  • Leukemia
  • Lymphoma
  • Vitamin deficiency

ASJC Scopus subject areas

  • Otorhinolaryngology


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