TY - JOUR
T1 - Organ-specific, phylogenetic, and ontogenetic distribution of the epidermolysis bullosa acquisita antigen
AU - Paller, Amy S.
AU - Queen, Laurinda L.
AU - Woodley, David T.
AU - Lane, Alfred T.
AU - Gammon, W. Ray
AU - Briggaman, Robert A.
PY - 1986/4
Y1 - 1986/4
N2 - The organ-specific, phylogenetic, and ontogenetic distribution of the epidermolysis bullosa acquisita (EBA) antigen, a newly recognized basement membrane component, was determined using polyclonal sera from patients with EBA and a mouse monoclonal antibody, H3a. Both antibodies are distributed at the basement membrane zone of skin, oral, anal, and vaginal mucosae, and esophagus, but not in kidney, urinary bladder, lymph nodes, placenta, or blood vessels. Both polyclonal and monoclonal EBA antibodies react with a basement membrane antigen in primate and other mammalian skin, but not in avian, amphibian, or reptilian skin. The antigen is present initially in the 8-week-old human fetus, and increases in density until the adult linear pattern is reached at 15 weeks' gestational age.
AB - The organ-specific, phylogenetic, and ontogenetic distribution of the epidermolysis bullosa acquisita (EBA) antigen, a newly recognized basement membrane component, was determined using polyclonal sera from patients with EBA and a mouse monoclonal antibody, H3a. Both antibodies are distributed at the basement membrane zone of skin, oral, anal, and vaginal mucosae, and esophagus, but not in kidney, urinary bladder, lymph nodes, placenta, or blood vessels. Both polyclonal and monoclonal EBA antibodies react with a basement membrane antigen in primate and other mammalian skin, but not in avian, amphibian, or reptilian skin. The antigen is present initially in the 8-week-old human fetus, and increases in density until the adult linear pattern is reached at 15 weeks' gestational age.
UR - http://www.scopus.com/inward/record.url?scp=0022473479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022473479&partnerID=8YFLogxK
U2 - 10.1111/1523-1747.ep12285623
DO - 10.1111/1523-1747.ep12285623
M3 - Article
C2 - 3745957
AN - SCOPUS:0022473479
SN - 0022-202X
VL - 86
SP - 376
EP - 379
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 4
ER -