Organoapatite growth on an orthopedic alloy surface

Julia J. Hwang, Kevin Jaeger, James Hancock, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We report here a method to coat orthopedic metals with the artificial bone material organoapatite. The growth of organoapatite on titanium alloy surfaces of foils and porous cylinders involves sequential preadsorption of poly(L-lysine) and poly(L-glutamic acid) on metal, followed by exposure to organoapatite-precipitating solutions. The organoapatite characterization of the coating was carried out by transmission electron microscopy, electron diffraction, scanning electron microscopy, energy-dispersive X-ray scattering, powder X-ray diffraction, FT-IR, and elemental analysis. The preadsorbed poly(amino acids) in the form of a self-assembled bilayer of oppositely charged macromolecules can lead to a surface coverage of titanium alloy in the range of 70-90%. The deposition mechanisms could involve the surface capture of embryonic crystals and the nucleation of apatite on the bilayer. Bioabsorbable organoapatite could serve as a tissue-engineering scaffold for bone regeneration into porous implants.

Original languageEnglish (US)
Pages (from-to)504-515
Number of pages12
JournalJournal of Biomedical Materials Research
Volume47
Issue number4
DOIs
StatePublished - 1999

Keywords

  • Bone tissue engineering
  • Coating
  • Organoapatite
  • Poly(amino acid)
  • Titanium

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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