ORIENTED FIBRILLAR COLLAGEN AND ITS APPLICATION TO BIOMEDICAL DEVICES.

Kenneth E. Hughes*, David J. Fink, Timothy B. Hutson, Arthur Veis

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations

Abstract

Experiments have demonstrated that unique collagen matrix morphologies can be produced by controlling the conditions under which thermal gelation is carried out. Techniques were devised for studying three-dimensional fibril structures within thick collagen gels using optical and electron microscopy. In addition, the mechanical and optical properties of dehydrated collagen gels were evaluated. The results of these studies reveal a remarkable high-wet-strength collagen material having unique properties, including matrix orientation at the fibril level. These collagen matrices have been assembled into various configurations, including tubing, flat sheets, filamentous structures, and composites. The development of products containing such highly organized collagen matrices could lead to a new generation of sophisticated bio-materials.

Original languageEnglish (US)
Pages (from-to)146-165
Number of pages20
JournalJournal of the American Leather Chemists Association
Volume79
Issue number4
StatePublished - Apr 1 1983
EventUnknown conference - Hershey, PA, USA
Duration: Jun 22 1983Jun 22 1983

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Science(all)

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