Origin of porcine brain natriuretic peptide-like immunoreactive innervation of the middle cerebral artery in the rat

Selden E. Spencer; Melina R. Kibbe; Karen M. Hurley; Philip Needleman; Clifford B. Saper

doi:10.1016/0304-3940(91)90264-T

Origin of porcine brain natriuretic peptide-like immunoreactive innervation of the middle cerebral artery in the rat

Selden E. Spencer, Melina R. Kibbe, Karen M. Hurley, Philip Needleman, Clifford B. Saper^*

^*Corresponding author for this work

Surgery, Vascular Surgery Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We recently demonstrated that porcine brain natriuretic peptide-like immunoreactive (pBNPir) fibers innervate parts of the cardiovascular system, including the arteries comprising the circle of Willis. To determine the origin of this innervation, we used the retrograde fluorescent tracer Fast Blue dye combined with pBNP immunocytochemistry. Cells which project to the middle cerebral artery and were also pBNPir were found in the trigeminal, pterygopalatine and superior cervical ganglia bilaterally but not in the geniculate or otic ganglia. The majority of these double-labelled cells were found in the ipsilateral trigeminal (46%) and superior cervical ganglia (34%). A pBNP-like substance may be a natural vasodilator in sympathetic, sensory and to a lesser extent parasympathetic neurons innervating the cerebrovascular system.

Original language	English (US)
Pages (from-to)	217-220
Number of pages	4
Journal	Neuroscience Letters
Volume	128
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(91)90264-T
State	Published - Jul 22 1991

Funding

The authors thank Quan Hue Ha for excellent technical assistance. This work was supported by USPHS NS22835 and American Heart Association Wyeth-Ayerst Grant-in-Aid 881120, as well as the Brain Research Foundation and the William D. Mabie Research Fund. KMH was supported by individual NRSA MH09607 and SS by Clinician-Investigator Development Award NS01313.

Keywords

Atrial natriuretic peptide
Pterygopalatine ganglion
Superior cervical ganglion
Trigeminal ganglion
Vasodilator

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(91)90264-T

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title = "Origin of porcine brain natriuretic peptide-like immunoreactive innervation of the middle cerebral artery in the rat",

abstract = "We recently demonstrated that porcine brain natriuretic peptide-like immunoreactive (pBNPir) fibers innervate parts of the cardiovascular system, including the arteries comprising the circle of Willis. To determine the origin of this innervation, we used the retrograde fluorescent tracer Fast Blue dye combined with pBNP immunocytochemistry. Cells which project to the middle cerebral artery and were also pBNPir were found in the trigeminal, pterygopalatine and superior cervical ganglia bilaterally but not in the geniculate or otic ganglia. The majority of these double-labelled cells were found in the ipsilateral trigeminal (46%) and superior cervical ganglia (34%). A pBNP-like substance may be a natural vasodilator in sympathetic, sensory and to a lesser extent parasympathetic neurons innervating the cerebrovascular system.",

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note = "Funding Information: The authors thank Quan Hue Ha for excellent technical assistance. This work was supported by USPHS NS22835 and American Heart Association Wyeth-Ayerst Grant-in-Aid 881120, as well as the Brain Research Foundation and the William D. Mabie Research Fund. KMH was supported by individual NRSA MH09607 and SS by Clinician-Investigator Development Award NS01313.",

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AU - Hurley, Karen M.

AU - Needleman, Philip

AU - Saper, Clifford B.

N1 - Funding Information: The authors thank Quan Hue Ha for excellent technical assistance. This work was supported by USPHS NS22835 and American Heart Association Wyeth-Ayerst Grant-in-Aid 881120, as well as the Brain Research Foundation and the William D. Mabie Research Fund. KMH was supported by individual NRSA MH09607 and SS by Clinician-Investigator Development Award NS01313.

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N2 - We recently demonstrated that porcine brain natriuretic peptide-like immunoreactive (pBNPir) fibers innervate parts of the cardiovascular system, including the arteries comprising the circle of Willis. To determine the origin of this innervation, we used the retrograde fluorescent tracer Fast Blue dye combined with pBNP immunocytochemistry. Cells which project to the middle cerebral artery and were also pBNPir were found in the trigeminal, pterygopalatine and superior cervical ganglia bilaterally but not in the geniculate or otic ganglia. The majority of these double-labelled cells were found in the ipsilateral trigeminal (46%) and superior cervical ganglia (34%). A pBNP-like substance may be a natural vasodilator in sympathetic, sensory and to a lesser extent parasympathetic neurons innervating the cerebrovascular system.

AB - We recently demonstrated that porcine brain natriuretic peptide-like immunoreactive (pBNPir) fibers innervate parts of the cardiovascular system, including the arteries comprising the circle of Willis. To determine the origin of this innervation, we used the retrograde fluorescent tracer Fast Blue dye combined with pBNP immunocytochemistry. Cells which project to the middle cerebral artery and were also pBNPir were found in the trigeminal, pterygopalatine and superior cervical ganglia bilaterally but not in the geniculate or otic ganglia. The majority of these double-labelled cells were found in the ipsilateral trigeminal (46%) and superior cervical ganglia (34%). A pBNP-like substance may be a natural vasodilator in sympathetic, sensory and to a lesser extent parasympathetic neurons innervating the cerebrovascular system.

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KW - Superior cervical ganglion

KW - Trigeminal ganglion

KW - Vasodilator

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Origin of porcine brain natriuretic peptide-like immunoreactive innervation of the middle cerebral artery in the rat

Abstract

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Keywords

ASJC Scopus subject areas

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