Origin of porcine brain natriuretic peptide-like immunoreactive innervation of the middle cerebral artery in the rat

Selden E. Spencer, Melina R. Kibbe, Karen M. Hurley, Philip Needleman, Clifford B. Saper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We recently demonstrated that porcine brain natriuretic peptide-like immunoreactive (pBNPir) fibers innervate parts of the cardiovascular system, including the arteries comprising the circle of Willis. To determine the origin of this innervation, we used the retrograde fluorescent tracer Fast Blue dye combined with pBNP immunocytochemistry. Cells which project to the middle cerebral artery and were also pBNPir were found in the trigeminal, pterygopalatine and superior cervical ganglia bilaterally but not in the geniculate or otic ganglia. The majority of these double-labelled cells were found in the ipsilateral trigeminal (46%) and superior cervical ganglia (34%). A pBNP-like substance may be a natural vasodilator in sympathetic, sensory and to a lesser extent parasympathetic neurons innervating the cerebrovascular system.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalNeuroscience Letters
Volume128
Issue number2
DOIs
StatePublished - Jul 22 1991

Keywords

  • Atrial natriuretic peptide
  • Pterygopalatine ganglion
  • Superior cervical ganglion
  • Trigeminal ganglion
  • Vasodilator

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Origin of porcine brain natriuretic peptide-like immunoreactive innervation of the middle cerebral artery in the rat'. Together they form a unique fingerprint.

Cite this