Origin of rat β-globin haplotypes containing three and five genes

T. Paunesku, M. Stevanovic, D. Radosavljevic, R. Drmanac, R. Crkvenjakov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We have reported in rat three adult β-gene haplotypes containing either five or three genes. Detailed sequence analysis reveals that the leftmost gene is the major gene and that at the opposite end downstream lies the minor gene. All of the genes lying between them are minor-major hybrids indicating their origin by unequal crossing-over. In two haplotypes β-globin genes were found with an L1 element inserted directly into IVS2. The described results allow the formulation of a pathway of mutational events leading from the ancient two-β-gene rodent ancestor through a three-gene haplotype to five-gene haplotypes, one of which is postulated to have arisen in common laboratory strains since their capture in the wild.

Original languageEnglish (US)
Pages (from-to)407-422
Number of pages16
JournalMolecular biology and evolution
Volume7
Issue number5
StatePublished - Oct 2 1990

Keywords

  • globin genes
  • minor-major hybrid genes
  • numerous β-globin genes
  • rat haplotypes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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