Origins and Mechanisms of miRNAs and siRNAs

Richard W. Carthew; Erik J. Sontheimer

doi:10.1016/j.cell.2009.01.035

Origins and Mechanisms of miRNAs and siRNAs

Richard W. Carthew^*, Erik J. Sontheimer

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Review article › peer-review

3444 Scopus citations

Abstract

Over the last decade, ∼20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs-short interfering RNAs (siRNAs) and microRNAs (miRNAs)-act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment.

Original language	English (US)
Pages (from-to)	642-655
Number of pages	14
Journal	Cell
Volume	136
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2009.01.035
State	Published - Feb 20 2009

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Over the last decade, ∼20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs-short interfering RNAs (siRNAs) and microRNAs (miRNAs)-act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment.",

author = "Carthew, {Richard W.} and Sontheimer, {Erik J.}",

note = "Funding Information: We are grateful to members of our laboratories for stimulating discussions. This work was supported by National Institutes of Health grants GM077581 and GM068743 to R.W.C. and GM072830 to E.J.S.",

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N2 - Over the last decade, ∼20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs-short interfering RNAs (siRNAs) and microRNAs (miRNAs)-act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment.

AB - Over the last decade, ∼20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs-short interfering RNAs (siRNAs) and microRNAs (miRNAs)-act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment.

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Origins and Mechanisms of miRNAs and siRNAs

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