Orthogonal tandem catalysis

Tracy L. Lohr, Tobin J. Marks*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

220 Scopus citations


Tandem catalysis is a growing field that is beginning to yield important scientific and technological advances toward new and more efficient catalytic processes. 'One-pot' tandem reactions, where multiple catalysts and reagents, combined in a single reaction vessel undergo a sequence of precisely staged catalytic steps, are highly attractive from the standpoint of reducing both waste and time. Orthogonal tandem catalysis is a subset of one-pot reactions in which more than one catalyst is used to promote two or more mechanistically distinct reaction steps. This Perspective summarizes and analyses some of the recent developments and successes in orthogonal tandem catalysis, with particular focus on recent strategies to address catalyst incompatibility. We also highlight the concept of thermodynamic leveraging by coupling multiple catalyst cycles to effect challenging transformations not observed in single-step processes, and to encourage application of this technique to energetically unfavourable or demanding reactions.

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalNature chemistry
Issue number6
StatePublished - May 20 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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