Osmotic shifts, cerebral edema, and neurologic deterioration in severe hepatic encephalopathy

Eric Michael Liotta*, Anna L. Romanova, Bryan D. Lizza, Laura Jarmila Rasmussen-Torvik, Minjee Kim, Brandon Francis, Rajbeer Singh Sangha, Timothy J. Carroll, Daniel R Ganger, Daniela P Ladner, Andrew M Naidech, James J Paparello, Shyam Prabhakaran, Farzaneh A Sorond, Matthew Brandon Maas

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume and neurologic function in patients with liver failure and severe hepatic encephalopathy. Design: Retrospective analysis of brain CT scans and clinical data. Setting: Tertiary care hospital ICUs. Patients: Patients with acute or acute-on-chronic liver failure and severe hepatic encephalopathy. Interventions: Clinically indicated CT scans and serum laboratory studies. Measurements and Main Results: Change in intracranial cerebrospinal fluid volume between sequential CT scans was measured as a biomarker of acute brain volume change. Corresponding changes in serum osmolality, chemistry measurements, and Glasgow Coma Scale were determined. Associations with cerebrospinal fluid volume change and Glasgow Coma Scale change for initial volume change assessments were identified by Spearman's correlations (rs) and regression models. Consistency of associations with repeated assessments was evaluated using generalized estimating equations. Forty patients were included. Median baseline osmolality was elevated (310 mOsm/Kg [296-321 mOsm/Kg]) whereas sodium was normal (137 mEq/L [134-142 mEq/L]). Median initial osmolality change was 9 mOsm/kg (5-17 mOsm/kg). Neuroimaging consistent with increased brain volume occurred in 27 initial assessments (68%). Cerebrospinal fluid volume change was more strongly correlated with osmolality (r = 0.70; p = 4 × 10-7) than sodium (r = 0.28; p = 0.08) change. Osmolality change was independently associated with Glasgow Coma Scale change (p = 1 × 10-5) and cerebrospinal fluid volume change (p = 2.7 × 10-5) in initial assessments and in generalized estimating equations using all 103 available assessments. Conclusions: Acute decline in osmolality was associated with brain swelling and neurologic deterioration in severe hepatic encephalopathy. Minimizing osmolality decline may avoid neurologic deterioration.

Original languageEnglish (US)
Pages (from-to)280-289
Number of pages10
JournalCritical care medicine
Volume46
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Hepatic Encephalopathy
Brain Edema
Osmolar Concentration
Nervous System
Glasgow Coma Scale
Cerebrospinal Fluid
Brain
Sodium
Liver Failure
Tertiary Healthcare
Serum
Tertiary Care Centers
Neuroimaging
Electrolytes
Biomarkers

Keywords

  • Cerebral edema
  • Coma
  • Hepatic encephalopathy
  • Liver failure
  • Renal replacement therapy

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

@article{648f136425a945b3a30a2b603e18bb02,
title = "Osmotic shifts, cerebral edema, and neurologic deterioration in severe hepatic encephalopathy",
abstract = "Objectives: We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume and neurologic function in patients with liver failure and severe hepatic encephalopathy. Design: Retrospective analysis of brain CT scans and clinical data. Setting: Tertiary care hospital ICUs. Patients: Patients with acute or acute-on-chronic liver failure and severe hepatic encephalopathy. Interventions: Clinically indicated CT scans and serum laboratory studies. Measurements and Main Results: Change in intracranial cerebrospinal fluid volume between sequential CT scans was measured as a biomarker of acute brain volume change. Corresponding changes in serum osmolality, chemistry measurements, and Glasgow Coma Scale were determined. Associations with cerebrospinal fluid volume change and Glasgow Coma Scale change for initial volume change assessments were identified by Spearman's correlations (rs) and regression models. Consistency of associations with repeated assessments was evaluated using generalized estimating equations. Forty patients were included. Median baseline osmolality was elevated (310 mOsm/Kg [296-321 mOsm/Kg]) whereas sodium was normal (137 mEq/L [134-142 mEq/L]). Median initial osmolality change was 9 mOsm/kg (5-17 mOsm/kg). Neuroimaging consistent with increased brain volume occurred in 27 initial assessments (68{\%}). Cerebrospinal fluid volume change was more strongly correlated with osmolality (r = 0.70; p = 4 × 10-7) than sodium (r = 0.28; p = 0.08) change. Osmolality change was independently associated with Glasgow Coma Scale change (p = 1 × 10-5) and cerebrospinal fluid volume change (p = 2.7 × 10-5) in initial assessments and in generalized estimating equations using all 103 available assessments. Conclusions: Acute decline in osmolality was associated with brain swelling and neurologic deterioration in severe hepatic encephalopathy. Minimizing osmolality decline may avoid neurologic deterioration.",
keywords = "Cerebral edema, Coma, Hepatic encephalopathy, Liver failure, Renal replacement therapy",
author = "Liotta, {Eric Michael} and Romanova, {Anna L.} and Lizza, {Bryan D.} and Rasmussen-Torvik, {Laura Jarmila} and Minjee Kim and Brandon Francis and Sangha, {Rajbeer Singh} and Carroll, {Timothy J.} and Ganger, {Daniel R} and Ladner, {Daniela P} and Naidech, {Andrew M} and Paparello, {James J} and Shyam Prabhakaran and Sorond, {Farzaneh A} and Maas, {Matthew Brandon}",
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Osmotic shifts, cerebral edema, and neurologic deterioration in severe hepatic encephalopathy. / Liotta, Eric Michael; Romanova, Anna L.; Lizza, Bryan D.; Rasmussen-Torvik, Laura Jarmila; Kim, Minjee; Francis, Brandon; Sangha, Rajbeer Singh; Carroll, Timothy J.; Ganger, Daniel R; Ladner, Daniela P; Naidech, Andrew M; Paparello, James J; Prabhakaran, Shyam; Sorond, Farzaneh A; Maas, Matthew Brandon.

In: Critical care medicine, Vol. 46, No. 2, 01.02.2018, p. 280-289.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Osmotic shifts, cerebral edema, and neurologic deterioration in severe hepatic encephalopathy

AU - Liotta, Eric Michael

AU - Romanova, Anna L.

AU - Lizza, Bryan D.

AU - Rasmussen-Torvik, Laura Jarmila

AU - Kim, Minjee

AU - Francis, Brandon

AU - Sangha, Rajbeer Singh

AU - Carroll, Timothy J.

AU - Ganger, Daniel R

AU - Ladner, Daniela P

AU - Naidech, Andrew M

AU - Paparello, James J

AU - Prabhakaran, Shyam

AU - Sorond, Farzaneh A

AU - Maas, Matthew Brandon

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Objectives: We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume and neurologic function in patients with liver failure and severe hepatic encephalopathy. Design: Retrospective analysis of brain CT scans and clinical data. Setting: Tertiary care hospital ICUs. Patients: Patients with acute or acute-on-chronic liver failure and severe hepatic encephalopathy. Interventions: Clinically indicated CT scans and serum laboratory studies. Measurements and Main Results: Change in intracranial cerebrospinal fluid volume between sequential CT scans was measured as a biomarker of acute brain volume change. Corresponding changes in serum osmolality, chemistry measurements, and Glasgow Coma Scale were determined. Associations with cerebrospinal fluid volume change and Glasgow Coma Scale change for initial volume change assessments were identified by Spearman's correlations (rs) and regression models. Consistency of associations with repeated assessments was evaluated using generalized estimating equations. Forty patients were included. Median baseline osmolality was elevated (310 mOsm/Kg [296-321 mOsm/Kg]) whereas sodium was normal (137 mEq/L [134-142 mEq/L]). Median initial osmolality change was 9 mOsm/kg (5-17 mOsm/kg). Neuroimaging consistent with increased brain volume occurred in 27 initial assessments (68%). Cerebrospinal fluid volume change was more strongly correlated with osmolality (r = 0.70; p = 4 × 10-7) than sodium (r = 0.28; p = 0.08) change. Osmolality change was independently associated with Glasgow Coma Scale change (p = 1 × 10-5) and cerebrospinal fluid volume change (p = 2.7 × 10-5) in initial assessments and in generalized estimating equations using all 103 available assessments. Conclusions: Acute decline in osmolality was associated with brain swelling and neurologic deterioration in severe hepatic encephalopathy. Minimizing osmolality decline may avoid neurologic deterioration.

AB - Objectives: We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume and neurologic function in patients with liver failure and severe hepatic encephalopathy. Design: Retrospective analysis of brain CT scans and clinical data. Setting: Tertiary care hospital ICUs. Patients: Patients with acute or acute-on-chronic liver failure and severe hepatic encephalopathy. Interventions: Clinically indicated CT scans and serum laboratory studies. Measurements and Main Results: Change in intracranial cerebrospinal fluid volume between sequential CT scans was measured as a biomarker of acute brain volume change. Corresponding changes in serum osmolality, chemistry measurements, and Glasgow Coma Scale were determined. Associations with cerebrospinal fluid volume change and Glasgow Coma Scale change for initial volume change assessments were identified by Spearman's correlations (rs) and regression models. Consistency of associations with repeated assessments was evaluated using generalized estimating equations. Forty patients were included. Median baseline osmolality was elevated (310 mOsm/Kg [296-321 mOsm/Kg]) whereas sodium was normal (137 mEq/L [134-142 mEq/L]). Median initial osmolality change was 9 mOsm/kg (5-17 mOsm/kg). Neuroimaging consistent with increased brain volume occurred in 27 initial assessments (68%). Cerebrospinal fluid volume change was more strongly correlated with osmolality (r = 0.70; p = 4 × 10-7) than sodium (r = 0.28; p = 0.08) change. Osmolality change was independently associated with Glasgow Coma Scale change (p = 1 × 10-5) and cerebrospinal fluid volume change (p = 2.7 × 10-5) in initial assessments and in generalized estimating equations using all 103 available assessments. Conclusions: Acute decline in osmolality was associated with brain swelling and neurologic deterioration in severe hepatic encephalopathy. Minimizing osmolality decline may avoid neurologic deterioration.

KW - Cerebral edema

KW - Coma

KW - Hepatic encephalopathy

KW - Liver failure

KW - Renal replacement therapy

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U2 - 10.1097/CCM.0000000000002831

DO - 10.1097/CCM.0000000000002831

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EP - 289

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

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ER -