Osteoblast-directed osteoclast metabolism from patients with premature coronal synostosis

Jay M. Pensler*, Pravin Kumar Patel, Craig B. Langman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Osteoclasts were harvested from explants of five patients with premature unilateral coronal synostosis and plated on devitalized bovine bone wafers. The planar surface areas of resorption lacunae were quantitated by means of light microscopy and a digital imaging system. Osteoclasts isolated from involved regions of premature synostosis exhibited enhanced resorption when compared with osteoclasts isolated from noninvolved cranial bone in the same patients (p < 0.05). When the involved osteoclasts were exposed to conditioned media from noninvolved osteoblasts, the in vitro metabolism media from non-consistent with noninvolved osteoclasts. The results suggest there may be a primary cellular defect and that there appears to be a complex coupling between osteoblasts and osteoclast function that may lead to sutural synostosis.

Original languageEnglish (US)
Pages (from-to)1518-1521
Number of pages4
JournalPlastic and reconstructive surgery
Issue number6
StatePublished - May 1997

ASJC Scopus subject areas

  • Surgery


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