Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation

Keyphrases

• Alkaline Phosphatase 8%
• Alkaline Phosphatase Activity 8%
• Alkaline Phosphatase Gene 8%
• Ascorbic Acid 100%
• Bone Metastasis 8%
• Bone Microenvironment 8%
• Cell Culture 8%
• Cell-to-cell 8%
• Collagen 100%
• Collagen Matrix 16%
• Collagen Synthesis 16%
• Dominant Negative 8%
• Gli1 16%
• LNCaP 16%
• LNCaP Cells 16%
• Matrix Protein 8%
• MC3T3 50%
• Metastasis 8%
• Mixed Culture 8%
• Negative Type 8%
• Osteoblast 100%
• Osteoblast Differentiation 100%
• Overexpressing 8%
• Paracrine 100%
• Paracrine Interactions 8%
• Preosteoblast 33%
• Proline 8%
• Prostate Cancer Bone Metastasis 8%
• Prostate Cancer Cells 100%
• Prostate Carcinoma 8%
• Ptc1 8%
• Sonic Hedgehog 41%
• Sonic Hedgehog Pathway 100%
• Synergistic Effect 16%
• Transcription Factor 8%
• Type I Collagen 8%
• Ultrastructural Features 8%

Medicine and Dentistry

• Alkaline Phosphatase 15%
• Ascorbic Acid 63%
• Bone Metastasis 10%
• Cancer Cell 100%
• Collagen Synthesis 10%
• Collagen Type 1 5%
• Fibril 5%
• Hedgehog Signaling 100%
• Matrix Protein 5%
• MC3T3 31%
• Metastatic Carcinoma 5%
• Osteoblast 100%
• Proline 5%
• Prostate Cancer 100%
• Prostate Carcinoma 5%
• Sonic Hedgehog Protein 100%
• Transcription Factors 5%

Biochemistry, Genetics and Molecular Biology

• Alkaline Phosphatase 15%
• Ascorbic Acid 63%
• Cancer Cell 100%
• Cofactors 5%
• Collagen Synthesis 10%
• GLI1 5%
• Hedgehog Signaling Pathway 100%
• LNCaP 21%
• Matrix Protein 5%
• Mixed Cell Culture 5%
• Osteoblast 100%
• Proline 5%
• Ptc1 5%
• Sonic Hedgehog 100%
• Transcription Factors 5%
• Type I Collagen 5%