Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice

Gamze Kilic, Junfeng Wang, Beatriz Sosa-Pineda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Matricellular proteins mediate both tissue morphogenesis and tissue homeostasis in important ways because they modulate cell-matrix and cell-cell interactions. In this study, we found that the matricellular protein osteopontin (Opn) is a novel marker of undifferentiated pancreatic precursors and pancreatic ductal tissues in mice. Our analysis also underscored a specific, dynamic profile of Opn expression in embryonic pancreatic tissues that suggests the participation of this protein's function in processes involving cell migration, cell-cell interactions, or both. Surprisingly, our analysis of Opn-deficient pancreata did not reveal obvious alterations in the morphology or differentiation of these tissues. Therefore, in embryonic pancreatic tissues, it is possible that other proteins act redundantly to Opn or that this protein's 'function is dispensable for pancreas development. Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses.

Original languageEnglish (US)
Pages (from-to)1659-1667
Number of pages9
JournalDevelopmental Dynamics
Volume235
Issue number6
DOIs
StatePublished - Jun 2006

Keywords

  • Development
  • Embryo
  • Matricellular proteins
  • Mouse
  • Osteopontin
  • Pancreas
  • Pancreatic ducts
  • Pancreatic precursor

ASJC Scopus subject areas

  • Developmental Biology

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