O2 sensing, mitochondria and ROS signaling: The fog is lifting

Gregory B. Waypa, Kimberly A. Smith, Paul T. Schumacker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Mitochondria are responsible for the majority of oxygen consumption in cells, and thus represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years, a number of mechanisms to explain how mitochondria participate in oxygen sensing have been proposed. However, no consensus has been reached regarding how mitochondria could regulate transcriptional and post-translational responses to hypoxia. Nevertheless, a growing body of data continues to implicate a role for increased reactive oxygen species (ROS) signals from the electron transport chain (ETC) in triggering responses to hypoxia in diverse cell types. The present article reviews our progress in understanding this field and considers recent advances that provide new insight, helping to lift the fog from this complex topic.

Original languageEnglish (US)
Pages (from-to)76-89
Number of pages14
JournalMolecular Aspects of Medicine
StatePublished - Feb 1 2016


  • Hypoxia
  • electron transport chain
  • metabolism
  • oxidant signaling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry


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