Other Respiratory Viruses as a Cause of Community-Acquired Pneumonia

James M. Walter*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide. There is growing appreciation of the burden of noninfluenza viral pathogens in CAP. Due to multiple factors including pneumococcal vaccination programs, declining rates of cigarette smoking, an aging population, and increasingly sensitive diagnostic tests, respiratory viruses are now the most common pathogens detected in CAP, outpacing Streptococcus pneumoniae. Noninfluenza respiratory pathogens are widely accepted as causal pathogens in CAP including in immunocompetent patients. This review provides an overview of five noninfluenza respiratory viral pathogens commonly implicated in CAP pathogenesis: rhinovirus, human metapneumovirus, respiratory syncytial virus, human parainfluenza virus, and human adenoviruses. Nucleic acid amplification testing platforms and their impact on antimicrobial stewardship efforts are also considered.

Original languageEnglish (US)
Pages (from-to)579-591
Number of pages13
JournalSeminars in Respiratory and Critical Care Medicine
Volume41
Issue number4
DOIs
StatePublished - Aug 1 2020

Keywords

  • community-acquired pneumonia
  • human adenovirus
  • human metapneumovirus
  • nucleic acid amplification
  • respiratory syncytial virus
  • rhinovirus
  • viral pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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