Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease

Keyphrases

• Apoptosis 20%
• Cell Proliferation 20%
• Clinical Symptoms 20%
• Coloboma 20%
• Complex Phenotypes 20%
• Disease Association 20%
• Disease Pathogenesis 20%
• Eye Defects 100%
• Fertilization 40%
• Functional Assessment 20%
• Gain-of-function mutation 20%
• Gene Function 20%
• Genotype 20%
• Gill 20%
• Head Structure 20%
• Heterogeneous Disorder 20%
• Human Genetics 20%
• Hypothalamus 40%
• Loss Function 20%
• Low Expression 20%
• Mandible Defect 100%
• Multiple Defects 20%
• Orthodenticle Homeobox 2 40%
• Osmoregulation 20%
• Pituitary 100%
• Pituitary Growth Hormone 20%
• Pituitary Hormone Deficiency 60%
• Prolactin 40%
• Rare Genetic Variants 20%
• Reduced Cell 20%
• Sodium Influx 20%
• Variable Phenotype 20%
• Vertebrate Model 20%
• Zebrafish 100%

Biochemistry, Genetics and Molecular Biology

• Bovine Somatotropin 20%
• Cell Proliferation 20%
• Gene Function 20%
• Genetic Divergence 20%
• Genotyping 20%
• Growth Hormone 20%
• Human Genetics 20%
• Loss of Function Mutation 20%
• Mammalian Model 100%
• Orthodenticle Homeobox 2 40%
• Osmoregulation 20%
• Pituitary Hormone 60%
• Prolactin 40%
• Sodium Transport 20%
• Vertebrate Model 20%
• Zebra Fish 100%