Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

Perihilar Cholangiocarcinoma Collaboration Group

doi:10.1016/j.hpb.2021.04.011

Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

Perihilar Cholangiocarcinoma Collaboration Group

Surgery, Surgical Oncology Division

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000–2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. Results: Of 1128 pCCA patients, 34 (3.0%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p =.630). Complications (Clavien-Dindo grade ≥ 3) were more frequent in PSC pCCA (71% versus 44%, p =.003). The rate of posthepatectomy liver failure (21% versus 17%, p =.530) and 90-day mortality (12% versus 13%, p = 1.000) was similar for PSC and non-PSC patients. Conclusion: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.

Original language	English (US)
Pages (from-to)	1751-1758
Number of pages	8
Journal	HPB
Volume	23
Issue number	11
DOIs	https://doi.org/10.1016/j.hpb.2021.04.011
State	Published - Nov 2021

Funding

Hannes Jansson was supported by grants from the Royal Swedish Academy of Sciences and Region Stockholm . Ernesto Sparrelid was supported by grants from the Bengt Ihre Foundation , the Center for Innovative Medicine at Karolinska Institutet and Region Stockholm. The funding sources had no involvement in the design or conduct of the study, the writing of the report or the decision to submit the article for publication.

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/j.hpb.2021.04.011

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@article{9c18e4cccca04691a55c968e809ad254,

title = "Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study",

abstract = "Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000–2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. Results: Of 1128 pCCA patients, 34 (3.0%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p =.630). Complications (Clavien-Dindo grade ≥ 3) were more frequent in PSC pCCA (71% versus 44%, p =.003). The rate of posthepatectomy liver failure (21% versus 17%, p =.530) and 90-day mortality (12% versus 13%, p = 1.000) was similar for PSC and non-PSC patients. Conclusion: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.",

author = "{Perihilar Cholangiocarcinoma Collaboration Group} and Hannes Jansson and Olthof, {Pim B.} and Annika Bergquist and Ligthart, {Marjolein A.P.} and Silvio Nadalin and Troisi, {Roberto I.} and {Groot Koerkamp}, Bas and Ruslan Alikhanov and Hauke Lang and Alfredo Guglielmi and Matteo Cescon and Jarnagin, {William R.} and Luca Aldrighetti and {van Gulik}, {Thomas M.} and Ernesto Sparrelid and A. Andreou and F. Bartsch and C. Benzing and S. Buettner and I. Capobianco and R. Charco and {de Reuver}, {P. R.} and {de Savornin Lohman}, E. and Dejong, {C. H.C.} and M. Efanov and Erdmann, {J. I.} and Franken, {L. C.} and Giglio, {M. C.} and C. Gomez-Gavara and J. Hagendoorn and F. Heid and IJzermans, {J. N.M.} and G. Kazemier and Maithel, {S. K.} and M. Malago and Malik, {H. Z.} and Molenaar, {Q. I.} and P. Muiesan and Nooijen, {L. E.} and Nota, {C. L.M.} and {Olde Damink}, {S. W.M.} and J. Pratschke and Quinn, {L. M.} and F. Ratti and M. Ravaioli and Roberts, {K. J.} and J. Rolinger and A. Ruzzenente and E. Schadde and M. Schmelzle",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = nov,

doi = "10.1016/j.hpb.2021.04.011",

language = "English (US)",

volume = "23",

pages = "1751--1758",

journal = "HPB",

issn = "1365-182X",

publisher = "Elsevier B.V.",

number = "11",

}

TY - JOUR

T1 - Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis

T2 - an international multicentre study

AU - Perihilar Cholangiocarcinoma Collaboration Group

AU - Jansson, Hannes

AU - Olthof, Pim B.

AU - Bergquist, Annika

AU - Ligthart, Marjolein A.P.

AU - Nadalin, Silvio

AU - Troisi, Roberto I.

AU - Groot Koerkamp, Bas

AU - Alikhanov, Ruslan

AU - Lang, Hauke

AU - Guglielmi, Alfredo

AU - Cescon, Matteo

AU - Jarnagin, William R.

AU - Aldrighetti, Luca

AU - van Gulik, Thomas M.

AU - Sparrelid, Ernesto

AU - Andreou, A.

AU - Bartsch, F.

AU - Benzing, C.

AU - Buettner, S.

AU - Capobianco, I.

AU - Charco, R.

AU - de Reuver, P. R.

AU - de Savornin Lohman, E.

AU - Dejong, C. H.C.

AU - Efanov, M.

AU - Erdmann, J. I.

AU - Franken, L. C.

AU - Giglio, M. C.

AU - Gomez-Gavara, C.

AU - Hagendoorn, J.

AU - Heid, F.

AU - IJzermans, J. N.M.

AU - Kazemier, G.

AU - Maithel, S. K.

AU - Malago, M.

AU - Malik, H. Z.

AU - Molenaar, Q. I.

AU - Muiesan, P.

AU - Nooijen, L. E.

AU - Nota, C. L.M.

AU - Olde Damink, S. W.M.

AU - Pratschke, J.

AU - Quinn, L. M.

AU - Ratti, F.

AU - Ravaioli, M.

AU - Roberts, K. J.

AU - Rolinger, J.

AU - Ruzzenente, A.

AU - Schadde, E.

AU - Schmelzle, M.

PY - 2021/11

Y1 - 2021/11

N2 - Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000–2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. Results: Of 1128 pCCA patients, 34 (3.0%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p =.630). Complications (Clavien-Dindo grade ≥ 3) were more frequent in PSC pCCA (71% versus 44%, p =.003). The rate of posthepatectomy liver failure (21% versus 17%, p =.530) and 90-day mortality (12% versus 13%, p = 1.000) was similar for PSC and non-PSC patients. Conclusion: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.

AB - Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000–2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. Results: Of 1128 pCCA patients, 34 (3.0%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p =.630). Complications (Clavien-Dindo grade ≥ 3) were more frequent in PSC pCCA (71% versus 44%, p =.003). The rate of posthepatectomy liver failure (21% versus 17%, p =.530) and 90-day mortality (12% versus 13%, p = 1.000) was similar for PSC and non-PSC patients. Conclusion: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.

UR - http://www.scopus.com/inward/record.url?scp=85105451809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85105451809&partnerID=8YFLogxK

U2 - 10.1016/j.hpb.2021.04.011

DO - 10.1016/j.hpb.2021.04.011

M3 - Article

C2 - 33975797

AN - SCOPUS:85105451809

SN - 1365-182X

VL - 23

SP - 1751

EP - 1758

JO - HPB

JF - HPB

IS - 11

ER -

Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

Abstract

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