Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis

Charlene Dekonenko; Jason D. Fraser; Katherine J. Deans; Mary E. Fallat; Michael Helmrath; Rashmi Kabre; Charles M. Leys; R. Cartland Burns; Kristine Corkumd; Patrick A. Dillon; Cynthia Downard; Tiffany N. Wright; Samir K. Gadepalli; Julia E. Grabowski; Edward Hernandez; Ronald Hirschl; Kevin N. Johnson; Jonathan E. Kohler; Matthew P. Landman; Rachel M. Landisch; Amy E. Lawrence; Grace Z. Mak; Peter C. Minneci; Beth Rymeski; Thomas T. Sato; Bethany J. Slater; Shawn D. St. Peter

doi:10.1038/s41372-021-01093-8

Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis

Charlene Dekonenko, Jason D. Fraser, Katherine J. Deans, Mary E. Fallat, Michael Helmrath, Rashmi Kabre, Charles M. Leys, R. Cartland Burns, Kristine Corkumd, Patrick A. Dillon, Cynthia Downard, Tiffany N. Wright, Samir K. Gadepalli, Julia E. Grabowski, Edward Hernandez, Ronald Hirschl, Kevin N. Johnson, Jonathan E. Kohler, Matthew P. Landman, Rachel M. LandischAmy E. Lawrence, Grace Z. Mak, Peter C. Minneci, Beth Rymeski, Thomas T. Sato, Bethany J. Slater, Shawn D. St. Peter^*

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Objective: To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design: A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported. Result: There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%). Conclusion: This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.

Original language	English (US)
Pages (from-to)	1755-1759
Number of pages	5
Journal	Journal of Perinatology
Volume	41
Issue number	7
DOIs	https://doi.org/10.1038/s41372-021-01093-8
State	Published - Jul 2021

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1038/s41372-021-01093-8

Cite this

Dekonenko, C., Fraser, J. D., Deans, K. J., Fallat, M. E., Helmrath, M., Kabre, R., Leys, C. M., Burns, R. C., Corkumd, K., Dillon, P. A., Downard, C., Wright, T. N., Gadepalli, S. K., Grabowski, J. E., Hernandez, E., Hirschl, R., Johnson, K. N., Kohler, J. E., Landman, M. P., ... St. Peter, S. D. (2021). Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis. Journal of Perinatology, 41(7), 1755-1759. https://doi.org/10.1038/s41372-021-01093-8

@article{485b03edcdc14a23afbd2b220f4ea717,

title = "Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis",

abstract = "Objective: To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design: A retrospective study of 394 neonates with gastroschisis at 11 children{\textquoteright}s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher{\textquoteright}s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported. Result: There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%). Conclusion: This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.",

author = "Charlene Dekonenko and Fraser, {Jason D.} and Deans, {Katherine J.} and Fallat, {Mary E.} and Michael Helmrath and Rashmi Kabre and Leys, {Charles M.} and Burns, {R. Cartland} and Kristine Corkumd and Dillon, {Patrick A.} and Cynthia Downard and Wright, {Tiffany N.} and Gadepalli, {Samir K.} and Grabowski, {Julia E.} and Edward Hernandez and Ronald Hirschl and Johnson, {Kevin N.} and Kohler, {Jonathan E.} and Landman, {Matthew P.} and Landisch, {Rachel M.} and Lawrence, {Amy E.} and Mak, {Grace Z.} and Minneci, {Peter C.} and Beth Rymeski and Sato, {Thomas T.} and Slater, {Bethany J.} and {St. Peter}, {Shawn D.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2021",

month = jul,

doi = "10.1038/s41372-021-01093-8",

language = "English (US)",

volume = "41",

pages = "1755--1759",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Nature Publishing Group",

number = "7",

}

Dekonenko, C, Fraser, JD, Deans, KJ, Fallat, ME, Helmrath, M, Kabre, R, Leys, CM, Burns, RC, Corkumd, K, Dillon, PA, Downard, C, Wright, TN, Gadepalli, SK, Grabowski, JE, Hernandez, E, Hirschl, R, Johnson, KN, Kohler, JE, Landman, MP, Landisch, RM, Lawrence, AE, Mak, GZ, Minneci, PC, Rymeski, B, Sato, TT, Slater, BJ & St. Peter, SD 2021, 'Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis', Journal of Perinatology, vol. 41, no. 7, pp. 1755-1759. https://doi.org/10.1038/s41372-021-01093-8

TY - JOUR

T1 - Outcomes in gastroschisis

T2 - expectations in the postnatal period for simple vs complex gastroschisis

AU - Dekonenko, Charlene

AU - Fraser, Jason D.

AU - Deans, Katherine J.

AU - Fallat, Mary E.

AU - Helmrath, Michael

AU - Kabre, Rashmi

AU - Leys, Charles M.

AU - Burns, R. Cartland

AU - Corkumd, Kristine

AU - Dillon, Patrick A.

AU - Downard, Cynthia

AU - Wright, Tiffany N.

AU - Gadepalli, Samir K.

AU - Grabowski, Julia E.

AU - Hernandez, Edward

AU - Hirschl, Ronald

AU - Johnson, Kevin N.

AU - Kohler, Jonathan E.

AU - Landman, Matthew P.

AU - Landisch, Rachel M.

AU - Lawrence, Amy E.

AU - Mak, Grace Z.

AU - Minneci, Peter C.

AU - Rymeski, Beth

AU - Sato, Thomas T.

AU - Slater, Bethany J.

AU - St. Peter, Shawn D.

PY - 2021/7

Y1 - 2021/7

N2 - Objective: To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design: A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported. Result: There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%). Conclusion: This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.

AB - Objective: To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design: A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported. Result: There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%). Conclusion: This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85106431685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85106431685&partnerID=8YFLogxK

U2 - 10.1038/s41372-021-01093-8

DO - 10.1038/s41372-021-01093-8

M3 - Article

C2 - 34035447

AN - SCOPUS:85106431685

SN - 0743-8346

VL - 41

SP - 1755

EP - 1759

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 7

ER -

Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this