Outcomes of endoscopy and computed tomography in patients with chronic rhinosinusitis

Muhamad Amine, Lauren Lininger, Keith N. Fargo, Kevin C. Welch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: Chronic rhinosinusitis (CRS) is a common disease diagnosed based on a combination of symptoms, imaging, and/or endoscopy. Computed tomography (CT) is the gold standard in diagnosis of CRS due to inherent low sensitivity of endoscopy. We sought to assess the correlation between symptoms, endoscopy, and imaging in order to reduce the number of CTs without decreasing diagnostic accuracy. Methods: Retrospective review of a single practitioner's patients from 2008 to 2010 who presented for evaluation of CRS. Data on demographics, symptoms, and endoscopic and CT findings were collected and analyzed. Exclusion criteria included patients with prior surgery, no imaging, and those that failed to meet the 2007 CRS Task Force symptom criteria. Results: A total of 244 patients met the Task Force symptom criteria. Using CT as the gold standard, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of endoscopy alone was 36%, 95%, 89%, and 55%, respectively. The number of symptoms (NOS) strongly correlated with the absence or presence of disease (p < 0.01). Incorporating NOS into a CRS diagnostic algorithm improved sensitivity and NPV of nasal endoscopy to 82% and 79% while maintaining its specificity and PPV at 82% and 84%, respectively. Applying our algorithm retrospectively would have resulted in a reduction in the number of CTs by 69%, resulting in an acceptable 10% (n = 24/244) false negative rate and 8% (n = 20/244) false positive rate. Conclusion: Incorporating number of symptoms in a CRS diagnostic algorithm may drastically reduce the number of CTs needed. Clinical diagnostic accuracy is enhanced with this new algorithm while significantly reducing the cost and radiation burden of CTs.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalInternational Forum of Allergy and Rhinology
Issue number1
StatePublished - Jan 1 2013


  • Chronic rhinosinusitis
  • Computed tomography
  • Diagnosis
  • Nasal endoscopy
  • Symptoms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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