Outcomes of observation without empiric intravenous antibiotics in febrile, nonneutropenic pediatric oncology patients

Natalie Wu, William Muller, Elaine R Morgan

Research output: Contribution to journalArticle

Abstract

There are no consensus guidelines for management of pediatric oncology patients presenting with fever and nonneutropenia, with limited research into the outcomes of withholding empiric i.v. antibiotics. We conducted a prospective cohort study assessing the safety and efficacy of observing well-appearing patients presenting with fever and nonneutropenia (absolute neutrophil count ≥ 500 cells/mm 3 ). Of 238 episodes, 82.7% patients were observed with no infectious complications and low overall incidence of bacteremia (3.4%). There were no significant differences in individual clinical variables. We propose that observation alone in some well-appearing febrile pediatric oncology patients is safe and limits the use of unnecessary empiric antibiotics.

Original languageEnglish (US)
Article numbere27550
JournalPediatric Blood and Cancer
Volume66
Issue number3
DOIs
StatePublished - Mar 1 2019
Externally publishedYes

Fingerprint

Fever
Observation
Pediatrics
Anti-Bacterial Agents
Bacteremia
Individuality
Consensus
Neutrophils
Cohort Studies
Cell Count
Outcome Assessment (Health Care)
Prospective Studies
Guidelines
Safety
Incidence

Keywords

  • antibiotics
  • bacteremia
  • fever
  • nonneutropenia
  • observation
  • oncology
  • pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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Outcomes of observation without empiric intravenous antibiotics in febrile, nonneutropenic pediatric oncology patients. / Wu, Natalie; Muller, William; Morgan, Elaine R.

In: Pediatric Blood and Cancer, Vol. 66, No. 3, e27550, 01.03.2019.

Research output: Contribution to journalArticle

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