Outcomes of vagal nerve stimulation in a pediatric population: A single center experience

Camilla Yu, Sriram Ramgopal, Mark Libenson, Imane Abdelmoumen, Christine Powell, Kyle Remy, Joseph R. Madsen, Alexander Rotenberg, Tobias Loddenkemper*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Objective To evaluate the efficacy of vagus nerve stimulation (VNS) in pediatric patients with medically refractory epilepsy. Method We reviewed the medical records of 252 consecutive patients who underwent VNS implantation at a single center over a 5-year period. Patients with complete 6- and 12-month follow-up data were included. Analysis was also done across various subgroups including gender, age at implantation, seizure type, abnormal MRI findings pre-implantation, number of medications at baseline, history of SE, and duration of epilepsy. Results Complete follow-up data were available for 69 patients. Median seizure reduction for these patients was 50% (Q1: 0%; Q3: 73%) at 6 months and 40% (Q1: -25%; Q3: 75%) at 12 months. When stratified by baseline seizure frequency, there was a significant reduction from baseline of 61% at 6 months and 69% at 12 months for patients in the high-baseline frequency group. There were no significant reductions at month 6 or 12 months for the lower-baseline frequency group. Adverse events were reported in 40.6% (28 out of 69 patients). Six patients had the VNS removed for reasons including lack of efficacy and side effects and were excluded from the study group. Conclusion VNS provides significant seizure reduction, in particular in pediatric patients with a higher baseline seizure frequency.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalSeizure
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2014

Keywords

  • Brain stimulation
  • Cranial Nerve
  • Efficacy
  • Epilepsy
  • Medically refractory epilepsy
  • Outcome
  • Pediatric
  • Seizure
  • Seizure control
  • Stimulation
  • Vagus nerve stimulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Yu, C., Ramgopal, S., Libenson, M., Abdelmoumen, I., Powell, C., Remy, K., Madsen, J. R., Rotenberg, A., & Loddenkemper, T. (2014). Outcomes of vagal nerve stimulation in a pediatric population: A single center experience. Seizure, 23(2), 105-111. https://doi.org/10.1016/j.seizure.2013.10.002