Abstract
Aqueous outflow resistance of enucleated human eyes was measured at 7 and 25 mm Hg before and after partial and complete (12 clock hours) internal trabeculotomy. Following complete trabeculotomy, 71% of the resistance was eliminated at 25 mm Hg while only 49% was eliminated at 7 mm Hg. In contrast to published findings in eyes with intact trabecular meshwork where the resistance increased with increasing IOP (1), following complete trabeculotomy, the resistance decreased 2% per mm Hg with increasing IOP. Experiments with trabeculotomy limited to part of the circumference showed that a one hour trabeculotomy produced 41% (25 mm Hg) to 60% (7 mm Hg) of the effect of a twelve hour trabeculotomy. The results indicate that a surprisingly high fraction of aqueous outflow resistance resides in the distal aspects of the outflow system at normal IOP, and that this distal resistance drops as IOP is increased.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1233-1240 |
| Number of pages | 8 |
| Journal | Current eye research |
| Volume | 8 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1989 |
Funding
ACKNOWLEDGEMENT This study was supported by a grant from the National Eye Institute R01 EY01894 and R01 EY05503 and by the National Glaucoma Research Program, part of the American Health Assistance Foundation.
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience
- Ophthalmology