Outpatient total body irradiation prior to bone marrow transplantation in pediatric patients: A feasibility analysis

G. L. Applegate*, B. B. Mittaj, M. Kletzel, E. Morgan, P. Johnson, K. Danner, Maryanne Hoffman Marymont

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Outpatient total body irradiation (TBI) prior to bone marrow transplantation has been accomplished in a total of 68 pediatric patients. The TBI regimen was fractionated with a total dose of 12 Gy in eight fractions twice daily. Antiemetic therapy consisted of oral ondansetron three times daily throughout the TBI course. Eight patients experienced mild nausea without vomiting, and four patients experienced mild nausea and vomiting. One patient required intravenous hydration after severe nausea and vomiting. Another patient experienced intractable diarrhea and dehydration which required inpatient management. Outpatient TBI prior to bone marrow transplantation is feasible in pediatric patients.

Original languageEnglish (US)
Pages (from-to)651-652
Number of pages2
JournalBone Marrow Transplantation
Volume21
Issue number7
DOIs
StatePublished - Apr 1 1998

Keywords

  • Marrow transplantation
  • Pediatric
  • TBI

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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