Outstanding questions in transplantation: Tolerance

Joseph R. Leventhal*, James M. Mathew

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


In 2017, the American Society of Transplantation (AST) launched the Outstanding Questions in Transplantation Research forum to stimulate a community-wide discussion of how the field is evolving and to help identify areas where a better dialogue between clinicians and researchers could result in great advancements. Tolerance emerged as a topic of great interest to the AST community. This minireview provides an overview of clinical transplantation tolerance. Historical background followed by a review of the current status of attempts to establish tolerance in the clinic, highlighting the dynamic online discussion surrounding this important topic from the AST Transplantation Research forum, is provided.

Original languageEnglish (US)
Pages (from-to)348-354
Number of pages7
JournalAmerican Journal of Transplantation
Issue number2
StatePublished - Feb 1 2020


  • immunosuppression/immune modulation
  • stem cells
  • tolerance: chimerism
  • tolerance: clinical
  • tolerance: mechanisms
  • translational research/science

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)


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